Mobarki Mousa, Papoudou-Bai Alexandra, Musawi Shaqraa, Péoc'h Michel, Karpathiou Georgia
Pathology Department, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia.
Pathology Department, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
Pathol Res Pract. 2024 Apr;256:155236. doi: 10.1016/j.prp.2024.155236. Epub 2024 Mar 2.
Ovarian fibromas are benign tumors that can present peculiar morphological features not studied sufficiently.
In this retrospective study, 75 consecutive cases of ovarian fibroma were morphologically compared with 46 thecomas, 16 granulosa cell tumors, and 5 sclerosing stroma tumors for the following factors: the growth pattern as diffuse or nodular, the presence of hyaline plaques, necrosis, keloid-like sclerosis, calcifications, cystic degeneration, fibrous or edematous stroma, prominent vascularity, lutein cells, cellularity, scant or abundant cytoplasm, prominent cell membranes, nuclear grooves, atypia, and mitotic activity.
The tumors differed significantly in terms of hyaline plaques presence, nuclear grooves, growth pattern, stroma type, tumor cellularity, cytoplasm, prominence of cell membranes, atypia, mitotic activity, and prominent vascularity.
Ovarian fibromas can present some maybe unexpected features rather frequently, such as cystic degeneration, hyaline plaques, prominent vascularity, increased cellularity, and some mitotic activity, thus their presence should not always prompt to an alternative diagnosis.
卵巢纤维瘤是良性肿瘤，可呈现一些尚未得到充分研究的特殊形态学特征。
在这项回顾性研究中，对75例连续的卵巢纤维瘤病例与46例卵泡膜瘤、16例颗粒细胞瘤和5例硬化性间质瘤进行了形态学比较，比较的因素包括：生长方式（弥漫性或结节性）、透明样斑块的存在、坏死、瘢痕疙瘩样硬化、钙化、囊性变、纤维性或水肿性间质、显著血管形成、黄体细胞、细胞密度、细胞质稀少或丰富、细胞膜突出、核沟、异型性和有丝分裂活性。
这些肿瘤在透明样斑块的存在、核沟、生长方式、间质类型、肿瘤细胞密度、细胞质、细胞膜突出、异型性、有丝分裂活性和显著血管形成方面存在显著差异。
卵巢纤维瘤可能相当频繁地呈现一些也许意想不到的特征，如囊性变、透明样斑块、显著血管形成、细胞密度增加和一些有丝分裂活性，因此其存在并不总是提示需要做出其他诊断。
