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胰高血糖素样肽-1受体激动剂在阻塞性睡眠呼吸暂停中的研究现状

[Research status of glucagon-like peptide-1 receptor agonists on obstructive sleep apnea].

作者信息

Zhou B N, Liu X, Hu K

机构信息

Second Department of Respiratory and Critical Care Medicine,Renmin Hospital of Wuhan University,Wuhan 430060,China.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 2024 Mar 12;47(3):281-285. doi: 10.3760/cma.j.cn112147-20230913-00155.

Abstract

Obstructive sleep apnea (OSA) is the most common sleep-disordered breathing disease. Continuous positive airway pressure (CPAP) is the gold standard for treatment, but compliance is suboptimal. Therefore, new therapeutic strategies need to be explored. OSA is often associated with multiple comorbidities, particularly type 2 diabetes and obesity. Effective weight loss is known to be crucial in reversing OSA and its associated comorbidities. However, sustained weight loss is difficult to achieve with lifestyle changes alone. Medications that have both hypoglycemic and weight-loss effects are one way to achieve this goal. This article discussed the therapeutic effect of glucagon-like peptide-1 receptor agonists on this disease.

摘要

阻塞性睡眠呼吸暂停(OSA)是最常见的睡眠呼吸紊乱疾病。持续气道正压通气(CPAP)是治疗的金标准,但依从性欠佳。因此,需要探索新的治疗策略。OSA常与多种合并症相关,尤其是2型糖尿病和肥胖症。众所周知,有效减重对于逆转OSA及其相关合并症至关重要。然而,仅通过生活方式改变很难实现持续减重。具有降糖和减重双重作用的药物是实现这一目标的一种方法。本文讨论了胰高血糖素样肽-1受体激动剂对该疾病的治疗效果。

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