Department of Pharmaceutics, ISF College of Pharmacy, Moga, 142001, Punjab, India.
Department of Quality Assurance, ISF College of Pharmacy, Moga, 142001, Punjab, India.
AAPS PharmSciTech. 2024 Mar 6;25(3):55. doi: 10.1208/s12249-024-02765-2.
Prostate cancer remains a significant global health concern, requiring innovative approaches for improved therapeutic outcomes. In recent years, nanoparticle-based drug delivery systems have emerged as promising strategies to address the limitations of conventional cancer chemotherapy. The key trends include utilizing nanoparticles for enhancing drug delivery to prostate cancer cells. Nanoparticles have some advantages such as improved drug solubility, prolonged circulation time, and targeted delivery of drugs. Encapsulation of chemotherapeutic agents within nanoparticles allows for controlled release kinetics, reducing systemic toxicity while maintaining therapeutic efficacy. Additionally, site-specific accumulation within the prostate tumor microenvironment is made possible by the functionalization of nanocarrier with targeted ligands, improving therapeutic effectiveness. This article highlights the basics of prostate cancer, statistics of prostate cancer, mechanism of multidrug resistance, targeting approach, and different types of nanocarrier used for the treatment of prostate cancer. It also includes the applications of nanocarriers for the treatment of prostate cancer and clinical trial studies to validate the safety and efficacy of the innovative drug delivery systems. The article focused on developing nanocarrier-based drug delivery systems, with the goal of translating these advancements into clinical applications in the future.
前列腺癌仍然是一个重大的全球健康问题，需要创新的方法来提高治疗效果。近年来，基于纳米粒子的药物传递系统已成为解决传统癌症化疗局限性的有前途的策略。主要趋势包括利用纳米粒子来增强对前列腺癌细胞的药物传递。纳米粒子具有一些优点，如提高药物溶解度、延长循环时间和药物的靶向递送。通过将化疗药物封装在纳米粒子内，可以实现控制释放动力学，在保持治疗效果的同时降低系统毒性。此外，通过靶向配体对纳米载体进行功能化，可以实现前列腺肿瘤微环境中的特定部位积累，从而提高治疗效果。本文重点介绍了前列腺癌的基础知识、前列腺癌的统计数据、多药耐药的机制、靶向方法以及用于治疗前列腺癌的不同类型的纳米载体。它还包括了纳米载体在治疗前列腺癌中的应用以及临床试验研究，以验证创新药物传递系统的安全性和疗效。本文侧重于开发基于纳米载体的药物传递系统，目标是将这些进展转化为未来的临床应用。
