Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
BMC Public Health. 2024 Mar 6;24(1):728. doi: 10.1186/s12889-024-18140-6.
Acute myocardial infarction is still a leading cause of death worldwide, accounting for roughly three million deaths yearly. This study aimed to investigate the prevalence and factors associated with ST-Segment Elevation Myocardial Infarction and Non-ST Segment Elevation Myocardial Infarction in Iran.
This cross-sectional study was conducted using the databases of the Fasa Registry on Acute Myocardial Infarction (FaRMI) and the Fasa Adult Cohort Study (FACS). chi-squared and one-way ANOVA tests were utilized to calculate the unadjusted associations between the study variables. A multivariate multinomial logistic regression model was also employed to determine the adjusted association of each independent variable with the risk of ST-elevation myocardial infarction (STEMI).
The prevalence of STEMI and non-STEMI was 31.60% and 11.80%, respectively. Multinomial logistic regression showed that older age, anemia, high WBC, and high creatinine levels were associated with higher odds of STEMI and non-STEMI compared to healthy individuals. In addition, based on the analysis being a woman(OR = 0.63,95%CI:0.51-0.78), anemia(OR = 0.67,95%CI:0.54-0.63)and hypertension (OR = 0.80,95%CI:0.65-0.97)decreased the likelihood of STEMI occurrence compared to non-STEMI, while high WBC(OR = 1.19,95%CI:1.15-1.23)increased the odds.
In this study, significant predictors of MI risk included age, gender, anemia, lipid profile, inflammation, and renal function. Subsequent investigations ought to prioritize the comprehensive understanding of the underlying mechanisms that drive these connections and assess the effectiveness of specific interventions aimed at diminishing the occurrence of MI and improving patient outcomes.
急性心肌梗死仍然是全球范围内导致死亡的主要原因，每年约有 300 万人因此死亡。本研究旨在调查伊朗 ST 段抬高型心肌梗死和非 ST 段抬高型心肌梗死的患病率及相关因素。
本横断面研究使用 Fasa 急性心肌梗死登记处（FaRMI）和 Fasa 成人队列研究（FACS）数据库进行。使用卡方检验和单因素方差分析检验研究变量之间的关联。还采用多变量多项逻辑回归模型来确定每个独立变量与 ST 段抬高型心肌梗死（STEMI）风险的调整关联。
STEMI 和非 STEMI 的患病率分别为 31.60%和 11.80%。多变量多项逻辑回归显示，与健康个体相比，年龄较大、贫血、白细胞计数较高和肌酐水平较高与 STEMI 和非 STEMI 的发生风险增加相关。此外，根据分析结果，与非 STEMI 相比，女性（OR=0.63，95%CI：0.51-0.78）、贫血（OR=0.67，95%CI：0.54-0.63）和高血压（OR=0.80，95%CI：0.65-0.97）降低了 STEMI 的发生概率，而白细胞计数较高（OR=1.19，95%CI：1.15-1.23）则增加了发病几率。
在本研究中，MI 风险的显著预测因素包括年龄、性别、贫血、血脂谱、炎症和肾功能。后续的研究应该优先全面了解导致这些关联的潜在机制，并评估旨在降低 MI 发生率和改善患者结局的特定干预措施的有效性。
