Rayhan Muhammad A, Mudatsir Mudatsir, Nurjannah Nurjannah, Ichsan Ichsan, Amir-Behghadami Mehrdad, Khader Yousef S, Koyanagi Ai, Sah Ranjit, Viveiros-Rosa Sandro G, Mamun Mohammed A, Lemu Yohannes K, Bouchra Assarag, Linguissi Laure Sg, Ikram Aamer, Sallam Dina E, Parperis Konstantinos, Wollina Uwe, Rademaker Marius, Vento Sandro, Usman Said
School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.
Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.
Narra J. 2022 Aug;2(2):e85. doi: 10.52225/narra.v2i2.85. Epub 2022 Aug 1.
Vaccines are urgently needed to control the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study was to determine the acceptance of and willingness to purchase a hypothetical COVID-19 vaccine in the general population of Aceh, a holistic Shariah law implementation province in Indonesia. An online cross-sectional study was conducted using a quota sampling technique between 1 to 24 September 2021. To determine hypothetical vaccine acceptance, respondents were asked if they were willing to accept vaccines with combinations of either 50% or 95% effectiveness and either 5% or 20% risk of adverse effects. Willingness to purchase was assessed by asking whether the participants would pay for such vaccines at certain price points. Logistic regression analysis was used to assess the associated determinants. Out of 377 respondents included in the final analysis, 86.5% were willing to accept a COVID-19 vaccine with 95% effectiveness and 5% adverse effects. The acceptance rate dropped to 45.1% if the risk of adverse effects was 20%. Vaccines with 50% effectiveness and 5% adverse effects were acceptable to 42.2% but the acceptance went down to 17.2% if the risk of adverse effects increased to 20%. Multivariate analysis found that men were twice as likely to accept a vaccine with 95% effectiveness and 5% adverse effects compared to females (aOR: 2.01; 95% CI 1.05-3.86). We found that 156/377 (41.3%) of respondents were willing to purchase a COVID-19 vaccine and of these participants 71.1% were willing to pay between Indonesian Rupiah (IDR) 50,000-150,000 (US$ 3.33-10.00). In conclusion, the acceptance rate of a hypothetical COVID-19 vaccine varied based on effectiveness and the risk of adverse effects.
迫切需要疫苗来控制2019冠状病毒病（COVID-19）大流行。本研究的目的是确定印度尼西亚全面实施伊斯兰教法的亚齐省普通民众对一种假设的COVID-19疫苗的接受程度和购买意愿。2021年9月1日至24日，采用配额抽样技术进行了一项在线横断面研究。为了确定对假设疫苗的接受程度，询问受访者是否愿意接受有效性为50%或95%、不良反应风险为5%或20%组合的疫苗。通过询问参与者是否会在特定价格点购买此类疫苗来评估购买意愿。采用逻辑回归分析来评估相关决定因素。在纳入最终分析的377名受访者中，86.5%的人愿意接受有效性为95%、不良反应为5%的COVID-19疫苗。如果不良反应风险为20%，接受率降至45.1%。有效性为50%、不良反应为5%的疫苗有42.2%的人可以接受，但如果不良反应风险增加到20%，接受率则降至17.2%。多变量分析发现，与女性相比，男性接受有效性为95%、不良反应为5%的疫苗的可能性是女性的两倍（调整后比值比：2.01；95%置信区间1.05-3.86）。我们发现，156/377（41.3%）的受访者愿意购买COVID-19疫苗，在这些参与者中，71.1%的人愿意支付50000-150000印尼盾（3.33-10.00美元）。总之，一种假设的COVID-19疫苗的接受率因有效性和不良反应风险而异。
