Craddock P R, Hammerschmidt D E, Moldow C F, Yamada O, Jacob H S
Semin Hematol. 1979 Apr;16(2):140-7.
Activation products of the terminal complement cascade potently affect granulocyte function, inducing, for example, their migration toward (chemotaxis), and adherence to (opsonization), microbes, and stimulating their production of microbicidal oxygen radicals such as superoxide anion, and the like. We present studies that demonstrate that a C5-derived peptide, probably C5a, is a potent promoter of granulocyte and monocyte adhesion to endothelium (margination) and, in addition, causes granulocyte autoaggregation in vitro and in vivo. Although possibly beneficial by producing phagocyte clumps to mechanically entrap unwanted microbes, such aggregates may be deleterious, particularly if sustained, especially in the lung.
补体终末级联反应的激活产物对粒细胞功能有显著影响，例如，诱导粒细胞向微生物迁移（趋化作用）、黏附于微生物（调理作用），并刺激其产生超氧阴离子等杀菌性氧自由基。我们的研究表明，一种C5衍生肽，可能是C5a，是粒细胞和单核细胞黏附于内皮细胞（边缘化）的强效促进剂，此外，还会在体外和体内导致粒细胞自动聚集。尽管产生吞噬细胞团块以机械性捕获有害微生物可能有益，但这种聚集可能有害，特别是如果持续存在，尤其是在肺部。
