Schmeling D J, Gemmell C G, Craddock P R, Quie P G, Peterson P K
Inflammation. 1981 Dec;5(4):313-22. doi: 10.1007/BF00911095.
The effect of staphylococcal alpha-toxin on the chemotactic response of human polymorphonuclear leukocytes was studied by measuring the migration of alpha-toxin-treated cells either through membrane filters toward C5a or under agarose toward N-formyl-l-methionyl-l-phenylalanine. At doses of greater than or equal to 5 hemolytic units, alpha-toxin depressed chemotactic responsiveness in both best systems. Further studies revealed that alpha-toxin was also a potent granulocyte aggregant at doses similar to those necessary for depressed chemotactic capacity. It is proposed that the inhibitory effect of this membrane-active toxin on chemotactic function may be related to increased granulocyte adhesiveness and that the pathogenic properties of alpha-toxin may in part by explained by these effects.
通过测量经α毒素处理的细胞穿过膜滤器向C5a迁移或在琼脂糖下向N-甲酰-L-蛋氨酰-L-苯丙氨酸迁移的情况，研究了葡萄球菌α毒素对人多形核白细胞趋化反应的影响。在剂量大于或等于5个溶血单位时，α毒素在两种最佳系统中均降低了趋化反应性。进一步的研究表明，α毒素在与降低趋化能力所需剂量相似的剂量下也是一种有效的粒细胞聚集剂。有人提出，这种膜活性毒素对趋化功能的抑制作用可能与粒细胞黏附性增加有关，并且α毒素的致病特性可能部分由这些作用来解释。
