Xiangya Nursing School, Central South University, Changsha, China; Department of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Department of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Lab Invest. 2024 May;104(5):102044. doi: 10.1016/j.labinv.2024.102044. Epub 2024 Mar 5.
Silent information regulator type-1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase, is a member of the sirtuins family and has unique protein deacetylase activity. SIRT1 participates in physiological as well as pathophysiological processes by targeting a wide range of protein substrates and signalings. In this review, we described the latest progress of SIRT1 in pulmonary diseases. We have introduced the basic information and summarized the prominent role of SIRT1 in several lung diseases, such as acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, lung cancer, and aging-related diseases.
沉默信息调节因子 1 型（SIRT1）是烟酰胺腺嘌呤二核苷酸依赖性去乙酰化酶，是 sirtuins 家族的一员，具有独特的蛋白质去乙酰化酶活性。SIRT1 通过靶向广泛的蛋白质底物和信号通路，参与生理和病理生理过程。在这篇综述中，我们描述了 SIRT1 在肺部疾病中的最新进展。我们介绍了 SIRT1 的基本信息，并总结了 SIRT1 在几种肺部疾病中的突出作用，如急性肺损伤、急性呼吸窘迫综合征、慢性阻塞性肺疾病、肺癌和与衰老相关的疾病。
