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光动力疗法联合抗真菌药物治疗脓癣:6例报告及文献复习

Photodynamic therapy combined with antifungal drugs against kerion: A report of six cases and literature review.

作者信息

Chen Xiaoli, Liang Yujia, Guo Ziyu, Huang Ruiye, Zheng Wenai, Wu Weiwei, Li Wen

机构信息

Department of Plastic and Dermatologic Surgery, The Fifth People's Hospital of Hainan Province, Haikou, Hainan, China; Department of Plastic and Dermatological Surgery, Affiliated Dermatology Hospital of Hainan Medical University, Haikou, Hainan, China.

Department of Laboratory Medicine, The Fifth People's Hospital of Hainan Province, Haikou, Hainan, China.

出版信息

Photodiagnosis Photodyn Ther. 2024 Apr;46:104039. doi: 10.1016/j.pdpdt.2024.104039. Epub 2024 Mar 5.

DOI:10.1016/j.pdpdt.2024.104039
PMID:38452908
Abstract

Kerion, a severe manifestation of tinea capitis caused by dermatophytes, is a fungal skin disease primarily affecting children. This report discusses six cases of pediatric kerion that were successfully treated with a combination of photodynamic therapy (PDT) and antifungal agents. Additionally, we conducted a literature review, identifying and analyzing six published reports on kerion and tinea capitis. The characteristics and efficacies of these cases are summarized. In summary, early combination therapy and proactive pre-treatment interventions proved effective in maximizing therapeutic outcomes, reducing disease duration and minimizing adverse reactions such as cicatricial alopecia. This approach has emerged as a favorable choice for the treatment of kerion.

摘要

脓癣是一种由皮肤癣菌引起的头癣严重表现形式,是一种主要影响儿童的真菌性皮肤病。本报告讨论了6例采用光动力疗法(PDT)和抗真菌药物联合治疗成功的儿童脓癣病例。此外,我们进行了文献综述,识别并分析了6篇关于脓癣和头癣的已发表报告。总结了这些病例的特征和疗效。总之,早期联合治疗和积极的预处理干预措施在最大化治疗效果、缩短病程以及最小化诸如瘢痕性脱发等不良反应方面被证明是有效的。这种方法已成为治疗脓癣的一种理想选择。

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