Department of Dermatology, the Fifth People's Hospital of Hainan Province, 33, Southern Road of Longkun, Qiongshan District, Haikou, 570206, Hainan, China.
Department of Laboratory Medicine, the Fifth People's Hospital of Hainan Province, 33, Southern Road of Longkun, Qiongshan District, Haikou, 570206, Hainan, China.
Photodiagnosis Photodyn Ther. 2019 Sep;27:385-387. doi: 10.1016/j.pdpdt.2019.07.007. Epub 2019 Jul 10.
Kerion refers to the severe inflammatory reaction which occurs in some cases of fungal infection of the hair or hair follicles. Successful treatment is a challenge for the small number of kerion patients who show poor efficacy of oral antifungal agents. In recent years, photodynamic therapy (PDT) has been proven to be a useful treatment for a variety of fungal infections. In this case report, a 9-year-old Chinese girl presented with erythema, pustular and tender plaques on her scalp for 2 month. The diagnosis of kerion was made based on clinical features and positive mycological findings. After the disease relapsed with oral administration of itraconazole for 6 weeks, she was successfully cured by three sessions of ALA-PDT combined with itraconazole. This case report suggests that ALA-PDT provides a good alternative and adjutant choice for kerion with safety, less side effects, and good repeatability.
头疮是指在某些情况下，真菌感染头发或毛囊时发生的严重炎症反应。少数头疮患者对口服抗真菌药物疗效不佳，成功治疗是一个挑战。近年来，光动力疗法（PDT）已被证明对多种真菌感染有效。在本病例报告中，一名 9 岁中国女孩头皮出现红斑、脓疱和触痛斑块 2 个月。根据临床特征和阳性真菌学发现，诊断为头疮。口服伊曲康唑治疗 6 周后疾病复发，经三次 ALA-PDT 联合伊曲康唑治疗后成功治愈。本病例报告提示 ALA-PDT 为头疮提供了一种安全、副作用少、可重复性好的替代和辅助选择。
