Department of Integrated Traditional Chinese and Western Medicine, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, China.
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu 210042, China.
Photodiagnosis Photodyn Ther. 2024 Feb;45:103954. doi: 10.1016/j.pdpdt.2023.103954. Epub 2023 Dec 23.
Dermatophytosis is the most common fungal infectious disease in the world, which is commonly caused by Trichophyton rubrum in China. The traditional therapies for treating dermatophytosis include topical and oral antifungal agents like terbinafine, griseofulvin, and azole antifungal drugs. However, 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) as a new alternative therapy avoids the side effects and drug resistance of traditional antifungal agents. We report two cases diagnosed as kerion and tinea faciei secondary to ulcers with CARD 9 deficiency, both of whom were infected by T.rubrum. They were both successfully treated by ALA-PDT combined with antifungal drugs, providing a feasible strategy for therapeutic choice for adult kerion and ulcer treatment.
皮肤癣菌病是世界上最常见的真菌性传染病，在中国主要由红色毛癣菌引起。治疗皮肤癣菌病的传统疗法包括局部和口服抗真菌药物，如特比萘芬、灰黄霉素和唑类抗真菌药物。然而，基于 5-氨基酮戊酸的光动力疗法（ALA-PDT）作为一种新的替代疗法，可以避免传统抗真菌药物的副作用和耐药性。我们报告了两例由 CARD9 缺陷引起的溃疡继发的脓癣和面癣，两者均由红色毛癣菌感染引起。他们都成功地通过 ALA-PDT 联合抗真菌药物治疗，为成人脓癣和溃疡治疗的治疗选择提供了一种可行的策略。
