Al-Faze Rawan, Ahmed Hoda A, El-Atawy Mohamed A, Zagloul Hayat, Alshammari Eida M, Jaremko Mariusz, Emwas Abdul-Hamid, Nabil Gehan M, Hanna Demiana H
Department of Chemistry, Faculty of Science, Taibah University, Almadinah Almunawarah, Saudi Arabia.
Chemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu, Saudi Arabia; Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
Biomed J. 2025 Feb;48(1):100714. doi: 10.1016/j.bj.2024.100714. Epub 2024 Mar 5.
Mitochondria are vital organelles found within living cells and have signalling, biosynthetic, and bioenergetic functions. Mitochondria play a crucial role in metabolic reprogramming, which is a characteristic of cancer cells and allows them to ensure a steady supply of proteins, nucleotides, and lipids to enable rapid proliferation and development. Their dysregulated activities have been associated with the growth and metastasis of different kinds of human cancer, particularly ovarian carcinoma. In this review, we briefly demonstrated the modified mitochondrial function in cancer, including mutations in mitochondrial DNA (mtDNA), reactive oxygen species (ROS) production, dynamics, apoptosis of cells, autophagy, and calcium excess to maintain cancer genesis, progression, and metastasis. Furthermore, the mitochondrial dysfunction pathway for some genomic, proteomic, and metabolomics modifications in ovarian cancer has been studied. Additionally, ovarian cancer has been linked to targeted therapies and biomarkers found through various alteration processes underlying mitochondrial dysfunction, notably targeting (ROS), metabolites, rewind metabolic pathways, and chemo-resistant ovarian carcinoma cells.
线粒体是存在于活细胞内的重要细胞器，具有信号传导、生物合成和生物能量功能。线粒体在代谢重编程中起着关键作用，这是癌细胞的一个特征，使它们能够确保蛋白质、核苷酸和脂质的稳定供应，以实现快速增殖和发展。它们的活动失调与不同类型的人类癌症，特别是卵巢癌的生长和转移有关。在这篇综述中，我们简要阐述了癌症中线粒体功能的改变，包括线粒体DNA（mtDNA）突变、活性氧（ROS）产生、动态变化、细胞凋亡、自噬以及钙过量，以维持癌症的发生、发展和转移。此外，还研究了卵巢癌中一些基因组、蛋白质组和代谢组学修饰的线粒体功能障碍途径。此外，卵巢癌与通过线粒体功能障碍的各种改变过程发现的靶向治疗和生物标志物有关，特别是针对（ROS）、代谢物、逆向代谢途径和化疗耐药的卵巢癌细胞。
