Lee Samantha S, Venniro Marco, Shaham Yavin, Hope Bruce T, Ramsey Leslie A
Behavioral Neuroscience Research Branch Intramural Research Program, National Institute On Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Psychopharmacology (Berl). 2025 May;242(5):1091-1102. doi: 10.1007/s00213-024-06560-6. Epub 2024 Mar 8.
We recently introduced a model of operant social reward in which female CD1 mice lever press for access to affiliative social interaction with a cagemate peer mouse of the same sex and strain. Here we determined the generality of the operant social self-administration model to male CD1 mice who, under certain conditions, will lever press to attack a subordinate male mouse.
We trained male CD1 mice to lever press for food and social interaction with a same sex and strain cagemate peer under different fixed-ratio (FR) schedule response requirements (FR1 to FR6). We then tested their motivation to seek social interaction after 15 days of isolation in the presence of cues previously paired with social self-administration. We also determined the effect of housing conditions on operant social self-administration and seeking. Finally, we determined sex differences in operant social self-administration and seeking, and the effect of housing conditions on unconditioned affiliative and antagonistic (aggressive) social interactions in both sexes.
Male CD1 mice lever pressed for access to a cagemate peer under different FR response requirements and seek social interaction after 15 isolation days; these effects were independent of housing conditions. There were no sex differences in operant social self-administration and seeking. Finally, group-housed CD1 male mice did not display unconditioned aggressive behavior toward a peer male CD1 mouse.
Adult socially housed male CD1 mice can be used in studies on operant social reward without the potential confound of operant responding to engage in aggressive interactions.
我们最近引入了一种操作性社会奖励模型，在该模型中，雌性CD1小鼠通过按压杠杆来获得与同性同品系的笼伴进行亲和性社会互动的机会。在此，我们确定了这种操作性社会自我给药模型对雄性CD1小鼠的适用性，这些雄性小鼠在某些条件下会按压杠杆以攻击从属雄性小鼠。
我们训练雄性CD1小鼠在不同的固定比率（FR）反应要求（FR1至FR6）下按压杠杆以获取食物并与同性同品系的笼伴进行社会互动。然后，在隔离15天后，在先前与社会自我给药配对的线索存在的情况下，测试它们寻求社会互动的动机。我们还确定了饲养条件对操作性社会自我给药和寻求行为的影响。最后，我们确定了操作性社会自我给药和寻求行为中的性别差异，以及饲养条件对两性无条件亲和性和对抗性（攻击性）社会互动的影响。
雄性CD1小鼠在不同的FR反应要求下按压杠杆以接近笼伴，并在隔离15天后寻求社会互动；这些影响与饲养条件无关。在操作性社会自我给药和寻求行为方面没有性别差异。最后，群居的CD1雄性小鼠对同性CD1同伴小鼠未表现出无条件的攻击行为。
成年群居雄性CD1小鼠可用于操作性社会奖励的研究，而不会出现因操作性反应引发攻击互动的潜在混淆因素。
