Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Curr Opin Neurobiol. 2021 Jun;68:67-75. doi: 10.1016/j.conb.2021.01.007. Epub 2021 Feb 4.
Mammalian social interactions are orchestrated by a wide array of neural circuits. While some aspects of social behaviors are driven by subcortical circuits, and are considered to be highly conserved and hard-wired, others require dynamic and context-dependent modulation that integrates current state, past experience and goal-driven action selection. These cognitive social processes are known to be dependent on the integrity of the prefrontal cortex. However, the circuit mechanisms through which the prefrontal cortex supports complex social functions are still largely unknown, and it is unclear if and how they diverge from prefrontal control of behavior outside of the social domain. Here we review recent studies exploring the role of prefrontal circuits in mammalian social functions, and attempt to synthesize these findings to a holistic view of prefrontal control of sociability.
哺乳动物的社会互动是由一系列广泛的神经回路来协调的。虽然某些社会行为的方面是由皮质下回路驱动的，并且被认为是高度保守和硬连线的，但其他方面则需要动态的、依赖上下文的调节，以整合当前状态、过去经验和目标驱动的行为选择。这些认知社会过程被认为依赖于前额叶皮层的完整性。然而，前额叶皮层支持复杂社会功能的回路机制在很大程度上仍然未知，也不清楚它们是否以及如何与前额叶皮层对社会领域以外的行为的控制相区别。在这里，我们回顾了最近探索前额叶回路在哺乳动物社会功能中的作用的研究，并试图将这些发现综合成一个整体的观点，即前额叶皮层对社交能力的控制。
