Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of Obstetrics, Zunyi Hospital of Traditional Chinese Medicine, Zunyi, China.
Curr Med Imaging. 2024;20:e15734056286027. doi: 10.2174/0115734056286027240118045347.
Extranodal NK/T-cell lymphoma (ENKTCL) is a type of malignant non-Hodgkin's lymphoma originating from mature T cells and NK cells, mainly involving the upper aerodigestive tract, including the nasal cavity, nasopharynx, oropharynx, oral cavity, hypopharynx, larynx, and occasionally the skin, salivary glands, testes, and gastrointestinal tract, but rarely the skeletal muscle.
An 82-year-old man presented with redness, swelling, and pain in his right lower limb for 3 months. He was initially diagnosed with cellulitis at another hospital and was treated conservatively for two weeks without improvement. He underwent a biopsy of the lesioned muscle and histopathology revealed nasal type ENKTCL. 18F-FDG PET/CT was recommended for the staging of the lymphoma, and the results showed that except for the muscles of the right lower extremity, no other organs and tissues were involved.
ENKTCL confined to the muscle of the lower extremity is rare and often initially misdiagnosed as myositis because of red, swollen, heat, and painful symptoms that resemble inflammation, and in it, higher radiotracer uptake in 18F-FDG PET/CT helps to distinguish it from myositis.
结外 NK/T 细胞淋巴瘤（ENKTCL）是一种起源于成熟 T 细胞和 NK 细胞的恶性非霍奇金淋巴瘤，主要累及上呼吸道，包括鼻腔、鼻咽、口咽、口腔、下咽、喉，偶尔也累及皮肤、唾液腺、睾丸和胃肠道，但很少累及骨骼肌。
一名 82 岁男性因右下肢红肿、疼痛 3 个月就诊。他最初在另一家医院被诊断为蜂窝织炎，并接受了两周的保守治疗，但没有改善。他接受了病变肌肉的活检，组织病理学显示为鼻型 ENKTCL。建议进行 18F-FDG PET/CT 分期检查，结果显示除右下肢肌肉外，无其他器官和组织受累。
局限于下肢肌肉的 ENKTCL 较为罕见，由于其红肿、热痛的症状类似于炎症，常被误诊为肌炎，而 18F-FDG PET/CT 中较高的放射性示踪剂摄取有助于将其与肌炎区分开来。
