Central Laboratory, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu, 215600, People's Republic of China.
School of Medicine, Zhenjiang, Jiangsu, 212013, People's Republic of China.
Int J Nanomedicine. 2021 Oct 23;16:7195-7229. doi: 10.2147/IJN.S334012. eCollection 2021.
Carbon quantum dots (CQDs) are an emerging class of quasi-zero-dimensional photoluminescent nanomaterials with particle sizes less than 10 nm. Owing to their favourable water dispersion, strong chemical inertia, stable optical performance, and good biocompatibility, CQDs have become prominent in biomedical fields. CQDs can be fabricated by "top-down" and "bottom-up" methods, both of which involve oxidation, carbonization, pyrolysis and polymerization. The functions of CQDs include biological imaging, biosensing, drug delivery, gene carrying, antimicrobial performance, photothermal ablation and so on, which enable them to be utilized in antitumour applications. The purpose of this review is to summarize the research progress of CQDs in antitumour applications from preparation and characterization to application prospects. Furthermore, the challenges and opportunities of CQDs are discussed along with future perspectives for precise individual therapy of tumours.
碳量子点（CQDs）是一类新兴的准零维光致发光纳米材料，其粒径小于 10nm。由于其良好的水分散性、较强的化学惰性、稳定的光学性能和良好的生物相容性，CQDs 在生物医学领域中备受关注。CQDs 可通过“自上而下”和“自下而上”的方法制备，这两种方法都涉及氧化、碳化、热解和聚合。CQDs 的功能包括生物成像、生物传感、药物输送、基因携带、抗菌性能、光热消融等，使其能够应用于抗肿瘤应用中。本文综述了 CQDs 在抗肿瘤应用中的研究进展，从制备和表征到应用前景进行了总结。此外，还讨论了 CQDs 的挑战和机遇，以及对肿瘤精准个体化治疗的未来展望。
