Department of Clinical Pharmacy, Faculty of Pharmacy, University of Science and Technology, Irbid, Jordan.
College of Pharmacy, AL Ain University, Abu Dhabi, United Arab Emirates.
Expert Rev Respir Med. 2024 Jan-Feb;18(1-2):59-65. doi: 10.1080/17476348.2024.2326512. Epub 2024 Mar 7.
This study investigated factors associated with anxiety and depression in COPD outpatients.
A cross-sectional study of 702 COPD outpatients from two major Jordanian hospitals using the Hospital Anxiety and Depression Scale (HADS) was conducted.
Significant associations were found with gender (Anxiety OR: 5.29, 95%CI: 2.38-11.74; Depression OR: 0.20, 95%CI: 0.08-0.51), disease severity (Anxiety OR: 2.97, 95%CI: 1.80-4.91; Depression OR: 15.95, 95%CI: 5.32-52.63), LABA use (Anxiety OR: 16.12, 95%CI: 8.26-32.26; Depression OR: 16.95, 95%CI: 8.33-34.48), medication count (Anxiety OR: 0.73, 95%CI: 0.59-0.90; Depression OR: 0.51, 95%CI: 0.40-0.64), mMRC score (Anxiety OR: 2.41, 95%CI: 1.81-3.22; Depression OR: 2.31, 95%CI: 1.76-3.03), and inhalation technique (Anxiety OR: 0.95, 95%CI: 0.93-0.97; Depression OR: 0.92, 95%CI: 0.90-0.95). Other factors associated with anxiety included high income, urban living, diabetes, hypertension, LAMA use, and fewer COPD medications. Depression was also linked with heart disease, increased age, and longer disease duration.
The prevalence of anxiety and depression among COPD patients necessitates targeted interventions. Future research that recruits a more diverse sample in multiple sites and establishes the cause-effect relationship between the study predictors and outcome could provide a more robust conclusion on factors associated with anxiety and depression among COPD patients.
本研究旨在调查 COPD 门诊患者焦虑和抑郁的相关因素。
采用医院焦虑抑郁量表（HADS）对来自两家约旦主要医院的 702 例 COPD 门诊患者进行横断面研究。
发现与性别（焦虑 OR：5.29，95%CI：2.38-11.74；抑郁 OR：0.20，95%CI：0.08-0.51）、疾病严重程度（焦虑 OR：2.97，95%CI：1.80-4.91；抑郁 OR：15.95，95%CI：5.32-52.63）、LABA 使用（焦虑 OR：16.12，95%CI：8.26-32.26；抑郁 OR：16.95，95%CI：8.33-34.48）、药物种类（焦虑 OR：0.73，95%CI：0.59-0.90；抑郁 OR：0.51，95%CI：0.40-0.64）、mMRC 评分（焦虑 OR：2.41，95%CI：1.81-3.22；抑郁 OR：2.31，95%CI：1.76-3.03）和吸入技术（焦虑 OR：0.95，95%CI：0.93-0.97；抑郁 OR：0.92，95%CI：0.90-0.95）相关。与焦虑相关的其他因素包括高收入、城市居住、糖尿病、高血压、LAMA 使用和较少的 COPD 药物。抑郁还与心脏病、年龄增长和疾病持续时间延长有关。
COPD 患者中焦虑和抑郁的患病率需要进行针对性干预。未来的研究可以在多个地点招募更多样化的样本，并确定研究预测因素与结果之间的因果关系，从而为 COPD 患者中焦虑和抑郁的相关因素提供更有力的结论。
