Choi Jinyong, Crotty Shane, Choi Youn Soo
Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Immune Netw. 2024 Feb 14;24(1):e8. doi: 10.4110/in.2024.24.e8. eCollection 2024 Feb.
Follicular helper T cells (Tfh) play a crucial role in generating high-affinity antibodies (Abs) and establishing immunological memory. Cytokines, among other functional molecules produced by Tfh, are central to germinal center (GC) reactions. This review focuses on the role of cytokines, including IL-21 and IL-4, in regulating B cell responses within the GC, such as differentiation, affinity maturation, and plasma cell development. Additionally, this review explores the impact of other cytokines like CXCL13, IL-10, IL-9, and IL-2 on GC responses and their potential involvement in autoimmune diseases, allergies, and cancer. This review highlights contributions of Tfh-derived cytokines to both protective immunity and immunopathology across a spectrum of diseases. A deeper understanding of Tfh cytokine biology holds promise for insights into biomedical conditions.
滤泡辅助性T细胞（Tfh）在产生高亲和力抗体（Abs）和建立免疫记忆方面发挥着关键作用。细胞因子是Tfh产生的众多功能分子之一，对生发中心（GC）反应至关重要。本综述重点关注细胞因子，包括IL-21和IL-4，在调节GC内B细胞反应中的作用，如分化、亲和力成熟和浆细胞发育。此外，本综述探讨了其他细胞因子如CXCL13、IL-10、IL-9和IL-2对GC反应的影响及其在自身免疫性疾病、过敏和癌症中的潜在作用。本综述强调了Tfh衍生细胞因子对一系列疾病的保护性免疫和免疫病理学的贡献。对Tfh细胞因子生物学的更深入理解有望为生物医学状况提供见解。
