P Kalyani, Selvarasu Kathiravan, Murthykumar Karthikeyan, Krishnan Murugesan, Kumar Santhosh P, Lakshmanan Saravanan
Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 Feb 6;16(2):e53696. doi: 10.7759/cureus.53696. eCollection 2024 Feb.
Background Surgical procedures such as excision of a growth or lesion lead to soft tissue or oral mucosal defects. These defects require a proper surgical dressing to promote better wound healing and to avoid infection and scarring. A collagen membrane is one of the most commonly used surgical dressings because of its ease of adaptability to defects and its inherent ability to promote epithelialization and inhibition of pain through the indirect mechanism of preventing infection of the surgical site. Collagen also serves as a reservoir of regenerative factors. The regenerative potential increases as porosity decreases. The novel bovine-derived collagen membrane used in this current study has an average porosity of 20 microns which increases the availability of regenerative factors. Objective The aim of this study was to compare the effectiveness between a novel matrix-modified bovine collagen membrane (SurgiColl) and a conventional bovine collagen membrane for promoting wound healing for oral mucosal or soft tissue defects. Materials and methods This clinical trial was conducted in the Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital. The sample size of the study was 20, divided into two groups: novel bovine collagen (Surgicoll-Mesh) (Group 1) and conventional bovine collagen (Group 2) with 10 participants in each group. The randomization process was adopted. The parameters assessed were epithelialization, granulation, and wound contraction at the end of two weeks. All the parameters were assessed using a standardized visual assessment scale. Statistical analysis was done using IBM SPSS Statistics for Windows, Version 23.0 (Released 2015; IBM Corp., Armonk, New York, United States), and an independent sample t-test was done at 95% confidence interval. A p-value of less than 0.05 was considered statistically significant. Results The difference in epithelialization between the two groups was statistically significant with a p-value of 0.015 (<0.05). The difference in granulation tissue formation between the two groups was statistically significant with a p-value of 0.015 (<0.05). The difference in wound contraction at the end of two weeks between the two groups was also statistically significant with a p-value of 0.005 (<0.05). Group 1 showed superior results compared to Group 2 for all the outcomes assessed. Conclusion The novel bovine-derived collagen membrane (SurgiColl-Mesh) was superior in its properties of wound healing for oral mucosal or soft tissue defects than the conventional bovine collagen membrane.
诸如切除肿物或病变等外科手术会导致软组织或口腔黏膜缺损。这些缺损需要合适的外科敷料来促进更好的伤口愈合，并避免感染和瘢痕形成。胶原膜是最常用的外科敷料之一，因为它易于适应缺损，并且具有通过防止手术部位感染的间接机制促进上皮形成和抑制疼痛的内在能力。胶原还可作为再生因子的储存库。随着孔隙率降低，再生潜力增加。本研究中使用的新型牛源胶原膜的平均孔隙率为20微米，这增加了再生因子的可用性。目的：本研究的目的是比较新型基质改性牛胶原膜（SurgiColl）和传统牛胶原膜在促进口腔黏膜或软组织缺损伤口愈合方面的有效性。材料和方法：本临床试验在Saveetha牙科学院和医院的口腔颌面外科进行。研究样本量为20例，分为两组：新型牛胶原（Surgicoll-Mesh）（第1组）和传统牛胶原（第2组），每组10名参与者。采用随机化过程。评估的参数为两周结束时的上皮形成、肉芽组织形成和伤口收缩。所有参数均使用标准化视觉评估量表进行评估。使用IBM SPSS Statistics for Windows，版本23.0（2015年发布；IBM公司，美国纽约州阿蒙克）进行统计分析，并在95%置信区间进行独立样本t检验。p值小于0.05被认为具有统计学意义。结果：两组之间上皮形成的差异具有统计学意义，p值为0.015（<0.05）。两组之间肉芽组织形成的差异具有统计学意义，p值为0.015（<0.05）。两组在两周结束时伤口收缩的差异也具有统计学意义，p值为0.005（<0.05）。在所有评估结果中，如果第1组和第2组相比，第1组显示出更好的结果。结论：新型牛源胶原膜（SurgiColl-Mesh）在促进口腔黏膜或软组织缺损伤口愈合的性能方面优于传统牛胶原膜。
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