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与世界卫生组织 2013 年关于严重急性营养不良管理指南相关的微量营养素补充实践。

Micronutrient supplementation practices in relation to the World Health Organisation 2013 guidelines on management of severe acute malnutrition.

机构信息

Centre of Excellence for Nutrition (CEN), Faculty of Health Science, North-West University, Potchefstroom, South Africa.

Department of Human Nutrition and Health, Faculty of Food and Human Science, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi.

出版信息

Matern Child Nutr. 2024 Jul;20(3):e13636. doi: 10.1111/mcn.13636. Epub 2024 Mar 8.

Abstract

In 2013, the World Health Organisation (WHO) updated the recommendations for micronutrient deficiency correction in hospitalised under-5 children with complicated severe acute malnutrition (SAM). This study aimed to describe the micronutrient deficiency correction practices in relation to WHO 2013 recommendations. Data from medical records of under-5 children admitted for SAM management at two hospitals in South Africa and three tertiary hospitals in Ghana were extracted. Micronutrient correction practices were compared to the WHO 2013 recommendations by considering the dosage, timing of micronutrient supplementation (vitamin A, iron and folic acid) and therapeutic feeds administered. In total, 723 medical records were included. Nearly half (48.3%) of the children received at least one of the studied micronutrients as a supplement. Vitamin A was supplemented in 27.4% of the children, while iron and folic acid were supplemented in 9.5% and 34.9%, respectively. Among the children who received vitamin A, 60.1% received the first dose on Day 1 of admission. Also, 46.4% of the iron-supplemented children received iron within the first week of admission. Vitamin A, iron and folic acid were administered within the dose range of 100,000-180,000 IU, 3.1-7.7 mg per kg per day, and 3-5 mg per day, respectively. Additionally, 71.7% of the children reportedly received therapeutic feeds that met WHO recommendations. The micronutrient deficiency correction practices regarding dose and timing differed from the 2013 WHO guidelines. Qualitative studies investigating the reasons for the disparities are recommended.

摘要

2013 年,世界卫生组织(WHO)更新了针对患有复杂严重急性营养不良(SAM)的住院 5 岁以下儿童微量营养素缺乏症纠正的建议。本研究旨在描述与 WHO 2013 年建议相关的微量营养素纠正做法。从南非两家医院和加纳三家三级医院收治的 SAM 管理的 5 岁以下儿童的病历中提取数据。通过考虑维生素 A、铁和叶酸的剂量、补充时间和给予的治疗性饲料,将微量营养素纠正做法与 WHO 2013 年的建议进行比较。共纳入 723 份病历。近一半(48.3%)的儿童接受了至少一种研究中的微量营养素补充剂。27.4%的儿童补充了维生素 A,9.5%和 34.9%的儿童补充了铁和叶酸。在接受维生素 A 的儿童中,60.1%在入院第一天接受了第一剂。此外,46.4%的补铁儿童在入院第一周内接受了补铁治疗。维生素 A、铁和叶酸的剂量范围分别为 100,000-180,000 IU、3.1-7.7 mg/kg/天和 3-5 mg/天。此外,据报道,71.7%的儿童接受了符合世卫组织建议的治疗性饲料。关于剂量和时间的微量营养素缺乏纠正做法与 2013 年世卫组织指南不同。建议进行定性研究,以调查差异的原因。

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