日益增强的认识：2000-2021 年犹他州对丁型肝炎病毒的检测和筛查存在局限性。
Growing Awareness: Limited Testing and Screening Bias for Hepatitis Delta Virus in Utah 2000-2021.
机构信息
School of Dentistry, University of Utah, Salt Lake City, Utah, USA.
Department of Gastroenterology and Hepatology, University of Utah, Salt Lake City, Utah, USA.
出版信息
J Infect Dis. 2024 Sep 23;230(3):e679-e683. doi: 10.1093/infdis/jiae023.
BACKGROUND
This study assessed the epidemiology of hepatitis delta virus (HDV) within the University of Utah UHealth health care system (2000-2021).
METHODS
Analysis of HDV/HBV testing, diagnostic codes, liver enzymes, and comorbidities was performed.
RESULTS
Among the 1962 HBV patients, only 22.2% underwent HDV testing, revealing an 8.3% positivity rate for HDV coinfections. This study observed a consistent increase in HBV and HDV cases, with higher HDV detection rates linked to increased testing. Limited HDV testing and potential screening biases were evident.
DISCUSSION
Improved HDV testing and surveillance are crucial for early detection and implementation of targeted therapies.
背景
本研究评估了犹他大学 UHealth 医疗保健系统（2000-2021 年）内的乙型肝炎 delta 病毒（HDV）的流行病学情况。
方法
对 HDV/HBV 检测、诊断代码、肝酶和合并症进行了分析。
结果
在 1962 名 HBV 患者中，仅有 22.2%接受了 HDV 检测，显示 HDV 合并感染的阳性率为 8.3%。本研究观察到 HBV 和 HDV 病例的持续增加，HDV 检测率的增加与检测的增加有关。HDV 检测有限且存在潜在的筛查偏倚。
讨论
改进 HDV 检测和监测对于早期发现和实施靶向治疗至关重要。
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