Department of Breast and Thyroid, Jinhua Central Hospital, Jinhua, China.
Department of Endocrinology and Metabolism, Jinhua People's Hospital, Jinhua, China.
Medicine (Baltimore). 2024 Mar 8;103(10):e37350. doi: 10.1097/MD.0000000000037350.
Mean corpuscular volume (MCV) is an important indicator used to determine the etiology of anemia and is associated with a variety of diseases. However, the link between thyroid function and MCV has yet to be clarified. This study was thus developed to assess relationships between thyroid function and MCV in a population of adults in the US. Results from the National Health and Nutrition Examination Survey study performed from 2007 to 2012 were used to conduct a cross-sectional analysis. Key thyroid-related variables included in this analysis were thyroid-stimulating hormone, total thyroxine (TT4), free triiodothyronine (FT3), total triiodothyronine (TT3), free thyroxine (FT4), antithyroglobulin, thyroglobulin, and antithyroid peroxidase levels. Generalized linear regression models were employed when estimating associations between MCV quartiles and thyroid parameters in 8104 adults 18 + years of age. In these participants, the weighted mean (SD) MCV was 89.36 (0.16) fL, with thyroid-stimulating hormone levels of 1.86 (0.03) mIU/mL, FT3 levels of 3.20 (0.01) pg/mL, FT4 levels of 0.80 (0.01) ng/dL, TT3 levels of 115.09 (0.64) ng/dL, and TT4 levels of 7.81 (0.04) μg/dL. When analyses were not adjusted, higher MCV values were related to reduced serum levels of FT3, TT3, or TT4. Following adjustment for possible confounding variables, this significant negative correlation between MCV and levels of FT3, TT3, and TT4 remained, and subgroup analysis revealed that this negative correlation was present in the male group and in the age group >50 years, but not in the female group and in the age group less than or equal to 50 years. These results suggest a significant negative correlation between MCV and FT3, TT3, and TT4, and this negative correlation originated more from the male population and those older than 50 years of age. The underlying mechanisms warrant additional investigation.
平均红细胞体积（MCV）是用于确定贫血病因的重要指标，与多种疾病有关。然而，甲状腺功能与 MCV 之间的联系尚未阐明。因此，本研究旨在评估美国成年人中甲状腺功能与 MCV 之间的关系。本研究使用了 2007 年至 2012 年进行的国家健康和营养检查调查研究的数据进行横断面分析。本分析中包含的关键甲状腺相关变量包括促甲状腺激素、总甲状腺素（TT4）、游离三碘甲状腺原氨酸（FT3）、总三碘甲状腺原氨酸（TT3）、游离甲状腺素（FT4）、抗甲状腺球蛋白、甲状腺球蛋白和抗甲状腺过氧化物酶水平。在 8104 名 18 岁及以上的成年人中，使用广义线性回归模型估计 MCV 四分位间距与甲状腺参数之间的关联。在这些参与者中，加权平均（SD）MCV 为 89.36（0.16）fL，促甲状腺激素水平为 1.86（0.03）mIU/mL，FT3 水平为 3.20（0.01）pg/mL，FT4 水平为 0.80（0.01）ng/dL，TT3 水平为 115.09（0.64）ng/dL，TT4 水平为 7.81（0.04）μg/dL。在未进行调整的分析中，较高的 MCV 值与血清 FT3、TT3 或 TT4 水平降低有关。在调整可能的混杂变量后，MCV 与 FT3、TT3 和 TT4 之间的这种显著负相关仍然存在，亚组分析显示这种负相关存在于男性组和年龄组大于 50 岁的人群中，但不存在于女性组和年龄组小于或等于 50 岁的人群中。这些结果表明 MCV 与 FT3、TT3 和 TT4 之间存在显著的负相关，这种负相关主要来自男性人群和年龄大于 50 岁的人群。潜在的机制需要进一步研究。
