Facultad de Medicina Clínica Alemana - Universidad del Desarrollo, Santiago, Chile.
Dermatology Service, Hospital Clínico de la Fuerza Aérea, Santiago, Chile.
Am J Dermatopathol. 2024 Apr 1;46(4):218-222. doi: 10.1097/DAD.0000000000002639.
Follicular dendritic cell sarcoma is a rare intermediate-grade malignancy characterized by a proliferation of ovoid to spindle-shaped cells with morphologic and immunophenotypic features similar to normal follicular dendritic cells. It may develop in lymph nodes or extranodal sites. Its presentation in extranodal tissues is a diagnostic challenge. It requires a high index of suspicion because follicular dendritic cell markers are not included in the routine immunohistochemical panels used for differential diagnosis. In an extensive review of the English literature, we found 3 cases of follicular dendritic cell sarcoma developing on the skin. We report a case of a primary cutaneous follicular dendritic cell sarcoma in a 28-year-old man, which presented as a 6-mm skin-colored nodule on the right forearm. We describe the morphologic and immunohistochemical features and a review of the literature.
滤泡树突状细胞肉瘤是一种罕见的中级恶性肿瘤，其特征是增生的卵圆形至梭形细胞，具有类似于正常滤泡树突状细胞的形态和免疫表型特征。它可能发生在淋巴结或结外部位。其在结外组织中的表现是一个诊断挑战。由于滤泡树突状细胞标志物不包括在用于鉴别诊断的常规免疫组织化学组合中，因此需要高度怀疑。在对英文文献的广泛回顾中，我们发现了 3 例发生在皮肤的滤泡树突状细胞肉瘤。我们报告了 1 例 28 岁男性的原发性皮肤滤泡树突状细胞肉瘤，其表现为右前臂 6mm 大小的肤色结节。我们描述了其形态学和免疫组织化学特征，并对文献进行了复习。
