Sahay Ayushi, Bal Munita, Patil Asawari, Kane Shubhada, Pai Prathamesh
Department of Pathology, Tata Memorial Center, MUMBAI, MAHARASHTRA, INDIA.
Turk Patoloji Derg. 2019;35(3):254-257. doi: 10.5146/tjpath.2017.01408.
Extranodal follicular dendritic cell sarcomas are extremely rare neoplasms included under the hematolymphoid and dendritic group of neoplasms. Histologically, fascicular, whorled spindle cells with sprinkled lymphocytes are typical; however higher grade epithelioid morphology seen in a subset makes diagnosis of follicular dendritic cell sarcoma challenging. Rarity of occurrence, a wide histologic spectrum and a long list of differential diagnostic entities render follicular dendritic cell sarcoma an under-recognized entity susceptible to diagnostic pitfalls. Application of a judicious panel of immunohistochemical markers is imperative to avoid errors in diagnosis and patient management. We report here an extremely rare case of follicular dendritic cell sarcoma of the larynx- a hitherto unreported site.
结外滤泡树突状细胞肉瘤是极其罕见的肿瘤，归属于血液淋巴和树突状肿瘤组。在组织学上，典型表现为束状、涡状排列的梭形细胞伴有散在淋巴细胞；然而，一部分病例中出现的高级别上皮样形态使得滤泡树突状细胞肉瘤的诊断具有挑战性。其发病率低、组织学谱广泛以及鉴别诊断实体众多，导致滤泡树突状细胞肉瘤成为一个认识不足且易出现诊断陷阱的实体。明智地应用一组免疫组化标志物对于避免诊断和患者管理中的错误至关重要。我们在此报告一例极其罕见的喉滤泡树突状细胞肉瘤——这是一个迄今为止尚未报道过的部位。
