Department of Pathophysiology, Medical College, Jiaying University, Meizhou, China.
Department of Nursing, Medical College, Jiaying University Meizhou, China.
Heart Lung. 2024 May-Jun;65:101-108. doi: 10.1016/j.hrtlng.2024.02.008. Epub 2024 Mar 8.
Growing evidence has shown that antioxidant diets protect against heart failure (HF). However, the association between the composite dietary antioxidant index (CDAI), an important measure of overall antioxidants in the diet, and HF has received little attention.
The purpose of this study was to examine the relationship between the CDAI and HF.
A secondary cross-sectional analysis of the 2003 to 2019 National Health and Nutrition Examination Survey (NHANES) was performed. Weighted multivariable logistic regression was used to test the association between the CDAI and HF in four different models, with subgroup analysis and an interaction test subsequently performed.
A total of 37,390 participants were included. The HF groups had lower CDAI levels than those in the non-HF group (0.29 ± 0.04 vs. -0.74 ± 0.16, p < 0.0001). After adjusting for demographic characteristics, lifestyle factors, and disease history, a negative association was found between the CDAI and HF (OR: 0.97, 95 % CI: 0.94, 1.00). There was an inverse trend whereby increasing the CDAI was associated with decreasing the odds of HF (p for trend < 0.001). The subgroup analysis and interaction test showed no significant dependence on demographic characteristics, lifestyle factors, and disease history with regard to this association (all p for interaction > 0.05).
The CDAI was inversely associated with HF in US adults, with higher CDAI levels possibly being associated with a lower incidence of HF, suggesting that dietary antioxidants may help prevent HF.
越来越多的证据表明，抗氧化饮食可预防心力衰竭（HF）。然而，复合饮食抗氧化指数（CDAI）作为饮食中总抗氧化剂的重要衡量指标，与 HF 之间的关联尚未得到充分关注。
本研究旨在探讨 CDAI 与 HF 之间的关系。
对 2003 年至 2019 年全国健康与营养调查（NHANES）进行二次横断面分析。采用加权多变量逻辑回归检验 CDAI 与 HF 之间的关联，随后进行亚组分析和交互检验。
共纳入 37390 名参与者。HF 组的 CDAI 水平低于非 HF 组（0.29 ± 0.04 与-0.74 ± 0.16，p < 0.0001）。在调整人口统计学特征、生活方式因素和疾病史后，发现 CDAI 与 HF 之间呈负相关（OR：0.97，95%CI：0.94，1.00）。随着 CDAI 的增加，HF 的几率呈下降趋势（趋势检验 p < 0.001）。亚组分析和交互检验显示，这种关联不受人口统计学特征、生活方式因素和疾病史的显著影响（交互检验 p 值均>0.05）。
在美国成年人中，CDAI 与 HF 呈负相关，较高的 CDAI 水平可能与 HF 发生率降低相关，提示饮食中的抗氧化剂可能有助于预防 HF。
