First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang, Hebei, 050011, People's Republic of China.
Hebei Key Laboratory of Integrative Medicine On Liver-Kidney Patterns, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, 050091, People's Republic of China.
BMC Public Health. 2024 Sep 2;24(1):2376. doi: 10.1186/s12889-024-19933-5.
The use of antioxidant-rich foods to treat female infertility has received significant attention in recent years. The aim of this study was to investigate the potential correlation between the composite dietary antioxidant index (CDAI) and female infertility.
The participants in the cross-sectional data were women between the ages of 20 and 45 who had complete CDAI-related data and infertility information, which were taken from the National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2020. The independent association between CDAI and infertility was investigated using multivariate logistic regression analysis. Trends between the two variables were examined using smoothed curve fitting, and subgroup analysis and interaction tests were conducted.
The prevalence of infertility was 12.57% of the 3,259 participants included in the study; individuals in higher CDAI quartiles tended to have a lower percentage of infertility. The risk of infertility was 44% lower among individuals in the highest quartile of the CDAI compared to those in the lowest quartile (OR = 0.56, 95%CI: 0.36-0.85, P = 0.0072), and the test for trend was also significant (P for trend = 0.0235). Smoothed curve fitting showed a negative non-linear relationship between CDAI and infertility. Subgroup analysis and interaction tests showed that there was an interaction of BMI in the relationship between CDAI and infertility risk (P for interaction = 0.0497) and that education, PIR, marital status, smoking status, hypertension, diabetes, age at menarche, ever having been treated for pelvic infection, ever having used female hormones, and ever been pregnant had no significant dependence on this negative association (all P for interaction > 0.05).
There was a negative non-linear correlation between CDAI and infertility among reproductive-aged women in the US. The risk of infertility may be reduced by increasing the intake of antioxidant-rich foods.
近年来，富含抗氧化剂的食物在治疗女性不孕方面受到了广泛关注。本研究旨在探讨复合膳食抗氧化指数（CDAI）与女性不孕之间的潜在相关性。
本横断面数据分析的对象为年龄在 20 至 45 岁之间的女性，她们具有完整的 CDAI 相关数据和不孕信息，这些数据来自于 2013 年至 2020 年期间进行的国家健康和营养检查调查（NHANES）。使用多变量逻辑回归分析调查了 CDAI 与不孕之间的独立关联。使用平滑曲线拟合检查了两个变量之间的趋势，进行了亚组分析和交互检验。
在纳入研究的 3259 名参与者中，不孕的患病率为 12.57%；CDAI 四分位较高的个体不孕的百分比较低。与 CDAI 四分位最低的个体相比，CDAI 四分位最高的个体不孕的风险降低了 44%（OR=0.56，95%CI：0.36-0.85，P=0.0072），趋势检验也具有显著性（P 趋势=0.0235）。平滑曲线拟合显示 CDAI 与不孕之间存在负非线性关系。亚组分析和交互检验表明，在 CDAI 与不孕风险之间的关系中，BMI 存在交互作用（P 交互=0.0497），而教育程度、皮褶厚度、婚姻状况、吸烟状况、高血压、糖尿病、初潮年龄、曾经接受过盆腔感染治疗、曾经使用过女性激素以及曾经怀孕与这种负相关没有显著依赖性（所有 P 交互>0.05）。
在美国生育年龄的女性中，CDAI 与不孕之间存在负非线性关系。增加富含抗氧化剂的食物的摄入可能会降低不孕的风险。
