Department of Mechanical Engineering, University College London, London WC1E 7JE, UK; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK; Department of Mechanical Engineering, Politeknik Negeri Malang, Jl. Soekarno Hatta No.9, Malang 65141, Jawa Timur, Indonesia.
Department of Mechanical Engineering, University College London, London WC1E 7JE, UK.
Int J Pharm. 2024 Apr 10;654:123972. doi: 10.1016/j.ijpharm.2024.123972. Epub 2024 Mar 7.
A core-sheath structure is one of the methods developed to overcome the challenges often faced when using monolithic fibers for drug delivery. In this study, fibers based on polyvinylpyrrolidone (core) and ethyl cellulose (sheath) were successfully produced using a novel core-sheath pressure-spinning process. For comparison, these two polymers were also processed into as blend fibers. All samples were then investigated for their performances in releasing water-soluble ampicillin (AMP) and poorly water-soluble ibuprofen (IBU) model drugs. Scanning electron,digital and confocal microscopy confirmed that fibers with a core-sheath structure were successfully made. Fourier transform infrared spectroscopy showed the success of the pressure-spinning technique in encapsulating AMP/IBU in all fiber samples. Compared to blend fibers, the core-sheath fibers had better performance in encapsulating both water-soluble and poorly water-soluble drugs. Moreover, the core-sheath structure was able to reduce the initial burst release and provided a better sustained release profile than the blend fiber analog. In conclusion, the pressure-spinning method was capable of producing core-sheath and blend fibers that could be used for the loading of either hydrophilic or hydrophobic drugs for controlled drug delivery systems.
核壳结构是克服使用整体纤维进行药物输送时经常面临的挑战的方法之一。在这项研究中，使用新型核壳压力纺丝工艺成功制备了基于聚乙烯吡咯烷酮（核）和乙基纤维素（壳）的纤维。为了进行比较，这两种聚合物也被加工成共混纤维。然后对所有样品进行研究，以评估它们在释放水溶性氨苄青霉素（AMP）和疏水性差的布洛芬（IBU）模型药物方面的性能。扫描电子显微镜、数字显微镜和共聚焦显微镜证实成功制备了具有核壳结构的纤维。傅里叶变换红外光谱表明压力纺丝技术成功地将 AMP/IBU 包封在所有纤维样品中。与共混纤维相比，核壳纤维在包封水溶性和疏水性药物方面具有更好的性能。此外，核壳结构能够减少初始突释，并提供比共混纤维类似物更好的持续释放曲线。总之，压力纺丝法能够制备可用于负载亲水性或疏水性药物的核壳纤维和共混纤维，以用于控制药物释放系统。
