Alajmi Ali, Niaz Ghassan, Chen Christine, Lee Kachiu
Main Line Center for Laser Surgery, Ardmore, Pennsylvania.
King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Dermatol Surg. 2024 May 1;50(5):467-470. doi: 10.1097/DSS.0000000000004114. Epub 2024 Mar 8.
Improving the appearance of lentigines on the hands is a key component to hand rejuvenation. Soft tissue fillers revolumize hands, but do not address pigmentary changes. OBJECTIVE: This study investigated the effiacy of a 15% trichloroacetic acid (TCA) + 3% glycolic acid (GA) combination peel in improvement of appearance of hand lentigines.
A prospective evaluator-blinded, split-hand study was performed using a 15% TCA + 3% GA peel to treat patients with hand lentigines. Subjects received a total of 3 treatments at 4-week intervals on 1 hand, with the other hand serving as an untreated control. Final photographs were taken 12 weeks after the last treatment. Two blinded board-certified dermatologists graded improvement in hand lentigines using a 5-point scale.
Eighteen of 20 patients completed the study (90%). The mean age was 64.4 years (SE 1.6, range 51-71). The mean pain scores were 3.8 (SE 0.4) on a 10-point scale (1 = no pain, 10 = extremely painful). Blinded evaluators correctly identified the after-treatment photographs in 16 patients (88%). Physician and patient-graded mean improvement of lentigines was significant for treated versus control hands ( p < .01). No adverse events were noted.
A series of three 15% TCA + 3% GA peels are effective and safe in the treatment of hand lentigines.
改善手部雀斑样痣外观是手部年轻化的关键组成部分。软组织填充剂可使手部恢复容积，但无法解决色素沉着变化问题。目的：本研究调查15%三氯乙酸（TCA）+3%乙醇酸（GA）联合化学剥脱术改善手部雀斑样痣外观的疗效。
采用前瞻性、评估者盲法、双手对照研究，使用15% TCA + 3% GA化学剥脱术治疗手部雀斑样痣患者。受试者一只手每隔4周接受共3次治疗，另一只手作为未治疗对照。最后一次治疗12周后拍摄最终照片。两名获得委员会认证的皮肤科医生采用5分制对手部雀斑样痣的改善情况进行盲法评分。
20例患者中有18例（90%）完成研究。平均年龄为64.4岁（标准误1.6，范围51 - 71岁）。10分制下平均疼痛评分为3.8（标准误0.4）（1 = 无疼痛，10 = 极其疼痛）。盲法评估者在16例患者（88%）中正确识别出治疗后的照片。与对照手相比，治疗手的医生和患者分级的雀斑样痣平均改善情况具有显著性差异（p < .01）。未观察到不良事件。
一系列三次15% TCA + 3% GA化学剥脱术治疗手部雀斑样痣有效且安全。
