从内生真菌双极草内生菌培养物中分离得到的三种新的古巴烯倍半萜类化合物。
Three new sativene sesquiterpenoids from cultures of endophytic fungus Bipolaris eleusines.
作者信息
Ai Hong-Lian, Yang Man-Si, Zi Shu-Hui, Guo Hua-Chun
机构信息
a School of Agriculture and Biological Technic, Yunnan Agricultural University , Kunming 650201 , China.
b Root and Tuber Crop Institute of Yunnan Agricultural University , Kunming 650201 , China.
出版信息
J Asian Nat Prod Res. 2015;17(10):982-7. doi: 10.1080/10286020.2015.1041929.
Three new sativene sesquiterpenoids, bipolenins A-C (1-3), together with two known analogs (4 and 5), were obtained from cultures of endophytic fungus Bipolaris eleusines. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses. Compound 2 showed weak inhibitory activities against lung cancer A-549 and breast cancer MCF-7 with IC50 values of 33.2 and 19.1 μmol, respectively.
从内生真菌稗草离蠕孢菌的培养物中获得了三种新的古巴烯倍半萜类化合物，双极菌素A - C（1 - 3），以及两种已知类似物（4和5）。通过广泛的光谱分析阐明了新化合物的结构。化合物2对肺癌A - 549和乳腺癌MCF - 7显示出微弱的抑制活性，IC50值分别为33.2和19.1 μmol。
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