Department of Epidemiology, School of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, China.
Department of Diagnostic Center, Kunshan Hospital of Traditional Chinese Medicine, Suzhou, China.
Am J Med Sci. 2024 Jul;368(1):48-54. doi: 10.1016/j.amjms.2024.02.013. Epub 2024 Mar 8.
Stroke is prevalent in hypertensive population. It has been suggested that unsaturated fatty acids (USFA) have protective effect on stroke. The effect of saturated fatty acids (SFAs) on stroke is still unclear. Therefore, we studied the relationship between circulating fatty acids and acute ischemic stroke (AIS) in hypertensive patients.
Eighty-nine pairs including 100 men and 78 women matched by sex and age were recruited. Each pair included a hypertensive patient within 48h of AIS onset and a hypertensive patient without stroke. Six circulating fatty acids were methylated before concentration determination which was repeated twice with percent recovery estimated.
There were differences in educational level (P = 0.002) and occupation (P < 0.001) between stroke and non-stroke participants. All the 6 fatty acid levels were higher in non-stroke participants (P = 0.017 for palmitoleic acid, 0.001 for palmitic acid, <0.001 for linoleic acid, <0.001 for behenic acid, <0.001 for nervonic acid and 0.002 for lignoceric acid). In logistic regression analysis, AIS was inversely associated with fatty acid levels except for lignoceric acid. After adjustment for education and occupation, the palmitoleic acid and palmitic acid levels were no longer inversely associated with AIS. After further adjustment for systolic blood pressure, smoking, drinking, total cholesterol and triglyceride, the inverse associations of linoleic acid (OR = 0.965, 95%CI = 0.942-0.990, P = 0.005), behenic acid (OR = 0.778, 95%CI = 0.664-0.939, P = 0.009), nervonic acid (OR = 0.323, 95%CI = 0.121-0.860, P = 0.024) with AIS remained significant.
Circulating fatty acids except lignoceric acid were inversely associated with AIS. Both USFAs and SFAs may have beneficial effect on stroke prevention in hypertensive population.
中风在高血压人群中很常见。有人认为不饱和脂肪酸（USFA）对中风有保护作用。饱和脂肪酸（SFAs）对中风的影响尚不清楚。因此，我们研究了高血压患者循环脂肪酸与急性缺血性中风（AIS）之间的关系。
招募了 89 对患者，包括 100 名男性和 78 名女性，按性别和年龄匹配。每对包括中风发作后 48 小时内的高血压患者和无中风的高血压患者。在浓度测定前，将 6 种循环脂肪酸甲基化，重复两次，估计回收率。
中风组和非中风组在受教育程度（P = 0.002）和职业（P < 0.001）方面存在差异。非中风组所有 6 种脂肪酸水平均较高（棕榈油酸 P = 0.017，棕榈酸 P = 0.001，亚油酸 P < 0.001，山嵛酸 P < 0.001，神经酸 P < 0.001，二十四烷酸 P = 0.002）。在逻辑回归分析中，除了二十四烷酸外，AIS 与脂肪酸水平呈负相关。在校正教育和职业后，棕榈油酸和棕榈酸水平与 AIS 不再呈负相关。在校正收缩压、吸烟、饮酒、总胆固醇和甘油三酯后，亚油酸（OR = 0.965，95%CI = 0.942-0.990，P = 0.005）、山嵛酸（OR = 0.778，95%CI = 0.664-0.939，P = 0.009）和神经酸（OR = 0.323，95%CI = 0.121-0.860，P = 0.024）与 AIS 的负相关仍然显著。
除二十四烷酸外，循环脂肪酸与 AIS 呈负相关。USFA 和 SFAs 可能对高血压人群预防中风都有有益作用。
