Physical Activity and Health Research Group ('PaHerg'), Research Institute of the Hospital 12 de Octubre ('imas12'), Madrid, Spain.
Department of Systems Biology, University of Alcalá, Madrid, Spain.
Nephrol Dial Transplant. 2024 Aug 30;39(9):1384-1391. doi: 10.1093/ndt/gfae062.
We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise intervention in affected patients. Physical activity/exercise might act as a polypill against CKD, preventing its development or even exerting beneficial effects once it is established (i.e. improvements in patients' physical fitness and cardiovascular risk, as well as in kidney function). Exercise benefits are also found at advanced CKD stages or in patients under hemodialysis. The biological mechanisms behind the clinical evidence are also discussed. An active lifestyle appears as a cornerstone in CKD prevention and management.
我们目前正面临着身体活动不足的大流行，这可能导致慢性肾脏病（CKD）的发病率不断上升。在这里，我们总结了目前关于身体活动与 CKD 之间关系的现有证据，并回顾了运动干预对受影响患者的影响。身体活动/运动可能是对抗 CKD 的“多效药丸”，可以预防其发展，甚至在其已经建立后（即改善患者的身体健康和心血管风险，以及肾功能）也能发挥有益作用。在晚期 CKD 阶段或血液透析患者中也能发现运动的益处。还讨论了临床证据背后的生物学机制。积极的生活方式似乎是 CKD 预防和管理的基石。
