Ren Jing-Yao, Xu Meng, Niu Xiang-Dong, Ma Shi-Xun, Jiao Ya-Jun, Wang Da, Yu Miao, Cai Hui
School of Clinical Medicine, Ningxia Medical University, Yinchuan 750000, Ningxia Hui autonomous region, China.
Gansu Provincial Hospital, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China.
World J Gastrointest Surg. 2024 Feb 27;16(2):382-395. doi: 10.4240/wjgs.v16.i2.382.
The systemic inflammatory response index (SIRI) has been demonstrated to make a significant difference in assessing the prognosis of patients with different solid neoplasms. However, research is needed to ascertain the accuracy and reliability of applying the SIRI to patients who undergo robotic radical gastric cancer surgery.
To validate the applicability of the SIRI in assessing the survival of gastric cancer patients and evaluate the clinical contribution of preoperative SIRI levels to predicting long-term tumor outcomes in patients, who received robotic radical gastric cancer surgery.
Initially, an exhaustive retrieval was performed in the PubMed, the Cochrane Library, EMBASE, Web of Science, and Scopus databases to identify relevant studies. Subsequently, a meta-analysis was executed on 6 cohort studies identifying the value of the SIRI in assessing the survival of gastric cancer patients. Additionally, the clinical data of 161 patients undergoing robotic radical gastric cancer surgery were retrospectively analyzed to evaluate their clinicopathological characteristics and relevant laboratory indicators. The association between preoperative SIRI levels and 5-year overall survival (OS) and disease-free survival (DFS) was assessed.
The findings demonstrated an extensive connection between SIRI values and the outcome of patients with gastric cancer. Preoperative SIRI levels were identified as an independent hazard feature for both OS and DFS among those who received robotic surgery for gastric cancer. SIRI levels in gastric cancer patients were observed to be associated with the presence of comorbidities, T-stage, carcinoembryonic antigen levels, the development of early serious postoperative complications, and the rate of lymph node metastasis.
SIRI values are correlated with adverse in the gastric cancer population and have the potential to be utilized in predicting long-term oncological survival in patients who undergo robotic radical gastric cancer surgery.
全身炎症反应指数（SIRI）已被证明在评估不同实体肿瘤患者的预后方面有显著差异。然而，需要开展研究以确定将SIRI应用于接受机器人根治性胃癌手术患者的准确性和可靠性。
验证SIRI在评估胃癌患者生存率方面的适用性，并评估术前SIRI水平对预测接受机器人根治性胃癌手术患者长期肿瘤结局的临床贡献。
首先，在PubMed、Cochrane图书馆、EMBASE、科学网和Scopus数据库中进行全面检索以确定相关研究。随后，对6项队列研究进行荟萃分析，确定SIRI在评估胃癌患者生存率方面的价值。此外，回顾性分析161例接受机器人根治性胃癌手术患者的临床资料，以评估其临床病理特征和相关实验室指标。评估术前SIRI水平与5年总生存率（OS）和无病生存率（DFS）之间的关联。
研究结果表明SIRI值与胃癌患者的预后存在广泛关联。术前SIRI水平被确定为接受机器人胃癌手术患者OS和DFS的独立危险因素。观察发现，胃癌患者的SIRI水平与合并症的存在、T分期、癌胚抗原水平、术后早期严重并发症的发生以及淋巴结转移率有关。
SIRI值与胃癌患者的不良预后相关，有可能用于预测接受机器人根治性胃癌手术患者的长期肿瘤生存情况。
