Zhang Junbin, Ding Yongfeng, Wang Weibin, Lu Yimin, Wang Haiyong, Wang Haohao, Teng Lisong
Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, China.
Cancer Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, China.
Gastroenterol Res Pract. 2020 Feb 25;2020:3207345. doi: 10.1155/2020/3207345. eCollection 2020.
Predicting the prognosis of gastric cancer using tumour-node-metastasis (TNM) staging is difficult as patients with the same TNM stage exhibit different prognoses.
This study investigated the prognostic value of the preoperative fibrinogen/albumin ratio (FAR)-systemic inflammation response index (SIRI) score in resectable gastric cancer (rGC).
Clinicopathological features of 231 rGC patients were analysed retrospectively. Patients were divided into three groups: FAR-SIRI score 2 (FAR ≥ 0.071 and SIRI ≥ 0.84), 1 (FAR < 0.071 and SIRI ≥ 0.84), and 0 (SIRI < 0.84). Higher FAR-SIRI scores were associated with larger tumours, poorer differentiation, and advanced TNM stage ( < 0.05). Compared to those with FAR-SIRI scores of 0, patients with scores of 2 had poorer overall survival (OS). The FAR-SIRI score was an independent prognostic factor for OS in rGC.
The present data demonstrated that FAR-SIRI scores predicted radical gastric cancer surgical outcomes and may serve as a blood marker for identifying high-risk patients.
由于处于相同肿瘤-淋巴结-转移（TNM）分期的胃癌患者预后不同，因此使用TNM分期预测胃癌预后具有一定难度。
本研究探讨了术前纤维蛋白原/白蛋白比值（FAR）-全身炎症反应指数（SIRI）评分在可切除胃癌（rGC）中的预后价值。
对231例rGC患者的临床病理特征进行回顾性分析。患者分为三组：FAR-SIRI评分2分（FAR≥0.071且SIRI≥0.84）、1分（FAR＜0.071且SIRI≥0.84）和0分（SIRI＜0.84）。较高的FAR-SIRI评分与肿瘤较大、分化较差及TNM分期较晚相关（＜0.05）。与FAR-SIRI评分为0分的患者相比，评分为2分的患者总生存期（OS）较差。FAR-SIRI评分是rGC患者OS的独立预后因素。
目前的数据表明，FAR-SIRI评分可预测胃癌根治性手术的结果，并可作为识别高危患者的血液标志物。
