Qiao Yuan, Xiao Jin, He Tongqiang, Wang Rui, Xu Yehong, Wei Yang, Wang Jun, Hu Rui, Li Zhibin
Obstetrics and Gynecology Intensive Care Unit, Northwest Women's and Children's Hospital No. 1616 Yanxiang Road, Xi'an 710061, Shaanxi, China.
Department of Obstetrics, Northwest Women's and Children's Hospital No. 1616 Yanxiang Road, Xi'an 710061, Shaanxi, China.
Am J Transl Res. 2024 Feb 15;16(2):567-576. doi: 10.62347/IVCJ9920. eCollection 2024.
To analyze the predictive value of coagulation function, alpha-fetoprotein (AFP) and placental growth factor (PIGF) for postpartum hemorrhage in patients with perilous placenta previa (PPP).
The clinical data of 104 PPP patients were retrospectively analyzed. The patients were divided into a hemorrhage group (n=68) and a non-hemorrhage group (n=36). A total of 55 healthy pregnant women were recruited as controls. The coagulation function, AFP and PIGF were compared between the three groups. Multivariate logistic regression was performed to determine independent risk factors for hemorrhage.
PT, TT, APTT, FIB and AFP were significantly higher while PIGF was lower in the PPP group than the control group (all P<0.05). Placental adhesion (OR 3.924, 95% CI 1.389-11.083, P=0.01), anterior placenta (OR 4.583, 95% CI 1.589-13.22, P=0.005), AFP (OR 0.208, 95% CI 0.068-0.635, P=0.006) and PIGF (OR 3.963, 95% CI 1.385-11.34, P=0.01) were independent risk factors for hemorrhage.
Coagulation function, AFP and PIGF could predict postpartum hemorrhage in PPP patients.
分析凝血功能、甲胎蛋白（AFP）和胎盘生长因子（PIGF）对凶险性前置胎盘（PPP）患者产后出血的预测价值。
回顾性分析104例PPP患者的临床资料。将患者分为出血组（n = 68）和非出血组（n = 36）。共纳入55例健康孕妇作为对照组。比较三组的凝血功能、AFP和PIGF。进行多因素logistic回归分析以确定出血的独立危险因素。
PPP组的PT、TT、APTT、FIB和AFP显著高于对照组，而PIGF低于对照组（均P < 0.05）。胎盘粘连（OR 3.924，95%CI 1.389 - 11.083，P = 0.01）、前置胎盘（OR 4.583，95%CI 1.589 - 13.22，P = 0.005）、AFP（OR 0.208，95%CI 0.068 - 0.635，P = 0.006）和PIGF（OR 3.963，95%CI 1.385 - 11.34，P = 0.01）是出血的独立危险因素。
凝血功能、AFP和PIGF可预测PPP患者的产后出血。
