Sun Mingzhe, Li Mengnan, Cui Xinwen, Yan Lin, Pei Yiqiao, Wang Chao, Guan Chunbo, Zhang Xiuqing
College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Health Foods R&D Office of Hebei Yiling Pharmaceutical Research Institute, Shijiazhuang 050035, China.
Heliyon. 2024 Mar 1;10(5):e26979. doi: 10.1016/j.heliyon.2024.e26979. eCollection 2024 Mar 15.
oil (SZSO) is a natural vegetable oil extracted from , a traditional Chinese medicine renowned for its sleep-promoting properties, while the mechanisms are still unclear. Our findings revealed that the terpenoids present in SZSO (T-SZSO) were identified as the active components responsible for promoting sleep. Network pharmacological analysis suggested that T-SZSO targeted different sleep-aid pathways to varying degrees and exhibited potential for preventing central nervous system diseases. Notably, lupeol and betulinicaldehyde exhibited more pronounced effects. Additionally, T-SZSO significantly elevated serotonin levels, enhanced gamma-aminobutyric acid (GABA) synthesis, promoted GABA A receptor expression, and decreased glutamate and norepinephrine expression levels. Moreover, T-SZSO was found to downregulate IL-1β expression while upregulating superoxide dismutase and inducible nitric oxide synthase levels. In conclusion, this study presents the first investigation into the pharmacological basis of SZSO in promoting sleep and highlights the potential of nature food in improving suboptimal health conditions.
酸枣仁油（SZSO）是一种从酸枣中提取的天然植物油，酸枣是一种以其助眠特性而闻名的传统中药，但其作用机制尚不清楚。我们的研究结果表明，酸枣仁油中的萜类化合物（T-SZSO）被确定为促进睡眠的活性成分。网络药理学分析表明，T-SZSO不同程度地靶向不同的助眠途径，并显示出预防中枢神经系统疾病的潜力。值得注意的是，羽扇豆醇和桦木醛表现出更显著的效果。此外，T-SZSO显著提高血清素水平，增强γ-氨基丁酸（GABA）合成，促进GABA A受体表达，并降低谷氨酸和去甲肾上腺素表达水平。此外，发现T-SZSO下调IL-1β表达，同时上调超氧化物歧化酶和诱导型一氧化氮合酶水平。总之，本研究首次对酸枣仁油促进睡眠的药理学基础进行了研究，并强调了天然食物在改善亚健康状况方面的潜力。
