Nie Li, Pan Xian-Li, Zhang Xiao-Bao, Zhang Shan, Rao Ji-Xian, Su Zeng-Feng
Department of General Medicine, Chaohu Hospital Affiliated with Anhui Medical University, Chaohu, China.
Front Psychiatry. 2022 Oct 18;13:1034405. doi: 10.3389/fpsyt.2022.1034405. eCollection 2022.
To investigate the changes in immunity and clinical infection events among patients with chronic insomnia.
Forty-two patients with chronic insomnia (age = 64.44 ± 10.53) and 47 normal controls (age = 67.08 ± 7.822) were selected to determine differences in data, such as complete blood counts (CBCs), biochemical indices, lymphocyte subsets, immunoglobulin (Ig), complement C3 and C4 and interleukin-6 (IL-6), as well as to compare the incidence of clinical infection between the two groups.
There were significant differences in erythrocyte, hemoglobin, hematocrit, albumin, globulin, creatinine, IgG, IgG/IgM ratio, CD4 T-lymphocytes, CD19-lymphocytes, CD4/CD8 ratio, platelet/lymphocyte ratio, CD19/CD3 ratio, and clinical infection events between the chronic insomnia group and the control group ( < 0.05). There was no significant difference in neutrophil, lymphocyte, monocyte, and platelet counts; lymphocyte subsets CD8 T and CD56; platelet-to-lymphocyte ratio (PLR); neutrophil-to-lymphocyte ratio (NLR); complement C3; complement C4; IgM; IgA; and IL-6 between the experimental group and their controls ( > 0.05). The systolic and diastolic blood pressures of the chronic insomnia group did not vary widely from those of the controls ( > 0.05).
Patients with chronic insomnia have immunological abnormalities, characterized by a higher incidence of clinical infection.
探讨慢性失眠患者免疫功能变化及临床感染事件。
选取42例慢性失眠患者（年龄=64.44±10.53）和47例正常对照者（年龄=67.08±7.822），测定血常规、生化指标、淋巴细胞亚群、免疫球蛋白（Ig）、补体C3和C4以及白细胞介素-6（IL-6）等数据差异，并比较两组临床感染发生率。
慢性失眠组与对照组在红细胞、血红蛋白、血细胞比容、白蛋白、球蛋白、肌酐、IgG、IgG/IgM比值、CD4 T淋巴细胞、CD19淋巴细胞、CD4/CD8比值、血小板/淋巴细胞比值、CD19/CD3比值及临床感染事件方面存在显著差异（<0.05）。实验组与对照组在中性粒细胞、淋巴细胞、单核细胞及血小板计数；淋巴细胞亚群CD8 T和CD56；血小板与淋巴细胞比值（PLR）；中性粒细胞与淋巴细胞比值（NLR）；补体C3；补体C4；IgM；IgA；及IL-6方面无显著差异（>0.05）。慢性失眠组收缩压和舒张压与对照组相比差异无统计学意义（>0.05）。
慢性失眠患者存在免疫异常，临床感染发生率较高。
