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缓解新生儿重症监护病房压力：新生大鼠的中医治疗方法

Alleviating Neonatal Intensive Care Unit Stress: A Chinese Medicine Approach in Neonatal Rats.

作者信息

Li Yingxin, Huang Xi, Hu Yanlin, Yang Liming, Zhang Xiujuan, Chen Qiong

机构信息

Department of Neonatology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, China.

出版信息

Biomed Res Int. 2024 Mar 2;2024:2733884. doi: 10.1155/2024/2733884. eCollection 2024.

DOI:10.1155/2024/2733884
PMID:38464682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10924680/
Abstract

BACKGROUND

Premature infants are exposed to numerous stressors in neonatal intensive care unit (NICU) during a crucial period for brain development; this period exerts long-term influences on cognitive and behavioral development.

AIMS

To evaluate the effect of NICU-related stress on neonatal rat pups and explore the effect of Chinese medicine treatment (CMT).

METHODS

Sixty male rat pups were randomly assigned to three groups: the control group, the NICU group (NICU-related stress), and the CMT group (NICU-related stress plus CMT). All stressors and interventions were administered from 0 to 7 days after birth. Body weight, serum corticosterone levels, and behavior in the open field (OF) test, elevated plus maze (EPM) test, sucrose preference test, and Morris water maze (MWM) test were recorded, and blood samples were collected at five different time points (T0, T1, T2, T3, and T4).

RESULTS

The body weights of rats in the CMT and control groups were heavier than those in the NICU group in both early life and adulthood ( < 0.05). Serum corticosterone levels significantly differed with time (except T0 vs. T1 and T3 vs. T4) but did not significantly differ among the three groups ( = 0.441, = 0.894). Regardless of age, spatial memory and anxiety-like and depression-like behavior did not differ among the three groups.

CONCLUSION

NICU-related stress exerted a long-term effect on rat growth and development but did not affect spatial memory, anxiety-like behavior, depression-like behavior, or serum corticosterone levels. CMT alleviated the impact of NICU-related stress on rats and promoted the growth and development of neonatal rats.

摘要

背景

早产儿在大脑发育的关键时期处于新生儿重症监护病房（NICU），面临众多应激源；这一时期对认知和行为发育具有长期影响。

目的

评估NICU相关应激对新生大鼠幼崽的影响，并探讨中医治疗（CMT）的作用。

方法

将60只雄性大鼠幼崽随机分为三组：对照组、NICU组（NICU相关应激）和CMT组（NICU相关应激加CMT）。所有应激源和干预措施均在出生后0至7天进行。记录体重、血清皮质酮水平，以及旷场（OF）试验、高架十字迷宫（EPM）试验、蔗糖偏好试验和莫里斯水迷宫（MWM）试验中的行为表现，并在五个不同时间点（T0、T1、T2、T3和T4）采集血样。

结果

CMT组和对照组大鼠在幼年和成年期的体重均高于NICU组（<0.05）。血清皮质酮水平随时间有显著差异（T0与T1、T3与T4除外），但三组间无显著差异（=0.441，=0.894）。无论年龄大小，三组间的空间记忆、焦虑样行为和抑郁样行为均无差异。

结论

NICU相关应激对大鼠生长发育有长期影响，但不影响空间记忆、焦虑样行为、抑郁样行为或血清皮质酮水平。CMT减轻了NICU相关应激对大鼠的影响，促进了新生大鼠的生长发育。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/10924680/751c468c645e/BMRI2024-2733884.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/10924680/831c2fed9e4b/BMRI2024-2733884.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/10924680/dcd13523801a/BMRI2024-2733884.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/10924680/a29f47be9067/BMRI2024-2733884.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/10924680/696d4d3c0de4/BMRI2024-2733884.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/10924680/751c468c645e/BMRI2024-2733884.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/10924680/831c2fed9e4b/BMRI2024-2733884.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/10924680/dcd13523801a/BMRI2024-2733884.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/10924680/a29f47be9067/BMRI2024-2733884.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/10924680/696d4d3c0de4/BMRI2024-2733884.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/10924680/751c468c645e/BMRI2024-2733884.005.jpg

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