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一种值得更广泛认识的严重右心衰竭的罕见病因。

An Unusual Etiology of Severe Right Heart Failure Deserving of Wider Recognition.

作者信息

Kang Woosun, Zong Yu, Patel Dhruvil Ashishkumar, Mishra Tushar, Afonso Luis

机构信息

Department of Cardiology, Wayne State University, Detroit, Michigan, USA.

Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA.

出版信息

JACC Case Rep. 2024 Jan 31;29(5):102222. doi: 10.1016/j.jaccas.2024.102222. eCollection 2024 Mar 6.

DOI:10.1016/j.jaccas.2024.102222
PMID:38464798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10920146/
Abstract

A previously healthy 31-year-old man presented with worsening shortness of breath and a petechial rash. Echocardiography showed severe right-sided heart failure with midsystolic notching of the antegrade right ventricular outflow Doppler envelope suggesting pulmonary hypertension. An extensive work-up revealed scurvy, with a dramatic resolution of symptoms shortly after vitamin C supplementation.

摘要

一名31岁既往健康的男性出现气短加重和瘀点皮疹。超声心动图显示严重的右侧心力衰竭,右心室流出道前向多普勒包络线在收缩中期出现切迹,提示肺动脉高压。全面检查发现为坏血病,补充维生素C后症状迅速缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/d489e10e0e49/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/66fed6c79117/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/c9feaed8fd41/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/0ae86562f004/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/0cd90018e6c8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/8fe8edafc5de/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/a16dd89ea312/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/d489e10e0e49/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/66fed6c79117/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/c9feaed8fd41/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/0ae86562f004/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/0cd90018e6c8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/8fe8edafc5de/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/a16dd89ea312/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4465/10920146/d489e10e0e49/gr6.jpg

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本文引用的文献

1
Therapy for Pulmonary Arterial Hypertension: Glance on Nitric Oxide Pathway.肺动脉高压的治疗:一氧化氮途径概述
Front Pharmacol. 2021 Nov 12;12:767002. doi: 10.3389/fphar.2021.767002. eCollection 2021.
2
Two Faces of Vitamin C-Antioxidative and Pro-Oxidative Agent.维生素 C 的双重面孔:抗氧化剂与促氧化剂。
Nutrients. 2020 May 21;12(5):1501. doi: 10.3390/nu12051501.
3
Vitamin C Induces the Reduction of Oxidative Stress and Paradoxically Stimulates the Apoptotic Gene Expression in Extravillous Trophoblasts Derived From First-Trimester Tissue.
维生素C可诱导氧化应激的减轻,且反常地刺激来自孕早期组织的绒毛外滋养层细胞中的凋亡基因表达。
Reprod Sci. 2015 Jul;22(7):783-90. doi: 10.1177/1933719114561561. Epub 2014 Dec 17.
4
Vitamin C deficiency in a population of young Canadian adults.加拿大年轻成年人人群中的维生素C缺乏情况。
Am J Epidemiol. 2009 Aug 15;170(4):464-71. doi: 10.1093/aje/kwp156. Epub 2009 Jul 13.