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金丝桃苷通过表皮生长因子受体-鼠肉瘤病毒癌基因同源物（EGFR-Ras）和Fas信号通路的相互作用诱导细胞周期停滞并抑制膀胱癌的发生。

Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways.

作者信息

Yang Kai, Qi Zhi-Xiang, Sun Ming-Xin, Xie Li-Ping

机构信息

Department of Urology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China.

出版信息

Int J Med Sci. 2024 Feb 12;21(4):690-702. doi: 10.7150/ijms.90261. eCollection 2024.

DOI:10.7150/ijms.90261
PMID:38464829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10920848/
Abstract

Hyperoside is a natural flavonol glycoside widely found in plants and has been reported to have a variety of pharmacological effects, including anticancer abilities. In this study, we demonstrated for the first time that hyperoside inhibited the proliferation of bladder cancer cells in vitro and in vivo. Moreover, hyperoside could not only induce cell cycle arrest, but also induce apoptosis of a few bladder cancer cells. Quantitative proteomics, bioinformatics analysis and Western blotting confirmed that hyperoside induced the overexpression of EGFR, Ras and Fas proteins, which affects a variety of synergistic and antagonistic downstream signaling pathways, including MAPKs and Akt, ultimately contributing to its anticancer effects in bladder cancer cells. This study reveals that hyperoside could be a promising therapeutic strategy for the prevention of bladder cancer.

摘要

金丝桃苷是一种广泛存在于植物中的天然黄酮醇苷，据报道具有多种药理作用，包括抗癌能力。在本研究中，我们首次证明金丝桃苷在体外和体内均能抑制膀胱癌细胞的增殖。此外，金丝桃苷不仅能诱导细胞周期停滞，还能诱导一些膀胱癌细胞凋亡。定量蛋白质组学、生物信息学分析和蛋白质印迹法证实，金丝桃苷诱导表皮生长因子受体（EGFR）、Ras和Fas蛋白的过表达，这影响了包括丝裂原活化蛋白激酶（MAPKs）和蛋白激酶B（Akt）在内的多种协同和拮抗的下游信号通路，最终促成其对膀胱癌细胞的抗癌作用。本研究表明，金丝桃苷可能是预防膀胱癌的一种有前景的治疗策略。

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本文引用的文献

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Hyperoside prevents high-fat diet-induced obesity by increasing white fat browning and lipophagy via CDK6-TFEB pathway.金丝桃苷通过CDK6-TFEB途径增加白色脂肪棕色化和脂肪自噬，预防高脂饮食诱导的肥胖。
J Ethnopharmacol. 2023 May 10;307:116259. doi: 10.1016/j.jep.2023.116259. Epub 2023 Feb 11.
2
Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity.桃叶珊瑚苷：结构、合成、药理学、药代动力学和毒性的综述。
Molecules. 2022 May 7;27(9):3009. doi: 10.3390/molecules27093009.
3
Hyperoside: A review on its sources, biological activities, and molecular mechanisms.
金丝桃苷：来源、生物活性和分子机制的综述。
Phytother Res. 2022 Jul;36(7):2779-2802. doi: 10.1002/ptr.7478. Epub 2022 May 13.
4
Cancer statistics, 2022.癌症统计数据，2022 年。
CA Cancer J Clin. 2022 Jan;72(1):7-33. doi: 10.3322/caac.21708. Epub 2022 Jan 12.
5
Hyperoside Ameliorates DSS-Induced Colitis through MKRN1-Mediated Regulation of PPARγ Signaling and Th17/Treg Balance.金丝桃苷通过 MKRN1 介导的 PPARγ 信号和 Th17/Treg 平衡调节改善 DSS 诱导的结肠炎。
J Agric Food Chem. 2021 Dec 22;69(50):15240-15251. doi: 10.1021/acs.jafc.1c06292. Epub 2021 Dec 8.
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Hyperoside suppresses BMP-7-dependent PI3K/AKT pathway in human hepatocellular carcinoma cells.金丝桃苷抑制人肝癌细胞中骨形态发生蛋白7（BMP-7）依赖的PI3K/AKT信号通路。
Ann Transl Med. 2021 Aug;9(15):1233. doi: 10.21037/atm-21-2980.
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