Oley Mendy Hatibie, Oley Maximillian Christian, Langi Fima Lanra Fredrik Gerald, Kepel Billy Johnson, Pajan Jacob, Kepel Regina Elizabeth Meriam, Wagiu Angelica Maurene Joicetine, Kalitouw Ferry, Kalesaran Laurens, Faruk Muhammad
Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia.
Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, R. D. Kandou Hospital, Manado, Indonesia.
Pan Afr Med J. 2023 Dec 27;46:117. doi: 10.11604/pamj.2023.46.117.41690. eCollection 2023.
COVID-19 causes a systemic inflammatory response, involving dysregulation and misexpression of many inflammatory cytokines. The recruitment and activation of inflammatory cells depend on the expression of many classes of inflammatory mediators, with increased expression of endothelial cell adhesion molecules being related to COVID-19 disease severity. With the World Health Organization having recently updated case definitions to suspect, probable, and confirmed, this study aimed to measure the mean value of intercellular adhesion molecule 1 (ICAM-1) and its relation to suspected COVID-19.
all suspected patients (n=20) were hospitalized and treated following the Indonesian National Guidelines for COVID-19 management. ICAM-1 levels were measured on days 1 and 7, demographic data were recorded, and routine blood count values were measured and additionally considered.
the results showed that the levels of ICAM-1 in the 1-day group (mean 271.3 ng/ml) were higher than those in the 7-day group (mean 253.9 ng/ml). This difference was statistically significant (p = 0.00, p ≤ 0.05). All of the patients with suspected COVID-19 were included in this study and tested for COVID-19 by reverse transcription polymerase chain reaction (RT-PCR) testing. A total of 10 patients were confirmed positive with a COVID-19 infection, with elevated ICAM-1 levels compared to the confirmed negative patients (with a mean 1 day 296.8 versus a mean 7th day 279.0 ng/ml). ICAM-1 levels of all patients decreased by the seventh day.
the mean value of ICAM-1 levels for patients with confirmed positive COVID-19 cases was higher than those with suspected COVID-19 cases.
新型冠状病毒肺炎（COVID-19）会引发全身炎症反应，涉及多种炎症细胞因子的失调和表达异常。炎症细胞的募集和激活取决于多种炎症介质的表达，内皮细胞黏附分子表达增加与COVID-19疾病严重程度相关。随着世界卫生组织最近更新了疑似、可能和确诊病例的定义，本研究旨在测量细胞间黏附分子1（ICAM-1）的平均值及其与疑似COVID-19的关系。
所有疑似患者（n = 20）均按照印度尼西亚国家COVID-19管理指南住院治疗。在第1天和第7天测量ICAM-1水平，记录人口统计学数据，并测量常规血常规值并加以考虑。
结果显示，第1天组的ICAM-1水平（平均271.3 ng/ml）高于第7天组（平均253.9 ng/ml）。这种差异具有统计学意义（p = 0.00，p≤0.05）。所有疑似COVID-19患者均纳入本研究，并通过逆转录聚合酶链反应（RT-PCR）检测进行COVID-19检测。共有10名患者确诊为COVID-19感染阳性，与确诊阴性患者相比，ICAM-1水平升高（第1天平均296.8 ng/ml，第7天平均279.0 ng/ml）。所有患者的ICAM-1水平在第7天时下降。
确诊为COVID-19阳性患者的ICAM-1水平平均值高于疑似COVID-19患者。
