Department of Infectious Diseases, Hunan Provincial People's Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, Hunan Provincial People's Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
J Infect Dis. 2020 Aug 17;222(6):894-898. doi: 10.1093/infdis/jiaa349.
In a retrospective study of 39 COVID-19 patients and 32 control participants in China, we collected clinical data and examined the expression of endothelial cell adhesion molecules by enzyme-linked immunosorbent assays. Serum levels of fractalkine, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular adhesion protein-1 (VAP-1) were elevated in patients with mild disease, dramatically elevated in severe cases, and decreased in the convalescence phase. We conclude the increased expression of endothelial cell adhesion molecules is related to COVID-19 disease severity and may contribute to coagulation dysfunction.
在一项对中国 39 例 COVID-19 患者和 32 例对照参与者的回顾性研究中，我们收集了临床数据，并通过酶联免疫吸附试验检测了内皮细胞黏附分子的表达。在轻症患者中，趋化因子 fractalkine、血管细胞黏附分子 1（VCAM-1）、细胞间黏附分子 1（ICAM-1）和血管黏附蛋白 1（VAP-1）的血清水平升高，在重症患者中显著升高，并在恢复期下降。我们得出结论，内皮细胞黏附分子的表达增加与 COVID-19 疾病的严重程度有关，可能导致凝血功能障碍。
