Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, China.
Food Funct. 2024 Apr 2;15(7):3552-3565. doi: 10.1039/d3fo03793b.
Osteoarthritis is the most prevalent degenerative joint disease reported worldwide. Conventional treatment strategies mainly focus on medication and involve surgical joint replacement. The use of these therapies is limited by gastrointestinal complications and the lifespan of joint prostheses. Hence, safe and efficacious drugs are urgently needed to impede the osteoarthritis progression. Urolithin B, a metabolite of ellagic acid in the gut, exhibits anti-inflammatory and antioxidant properties; however, its role in osteoarthritis remains unclear. In this study, we demonstrated that urolithin B efficiently inhibits the inflammatory factor-induced production of matrix metalloproteinases (MMP3 and MMP13) and upregulates the expression of type II collagen and aggrecan. Urolithin B alleviates cartilage erosion and osteophyte formation induced by anterior cruciate ligament transections. Moreover, urolithin B inhibits the activation of the NF-κB pathway by reducing the phosphorylation of Iκb-α and the nuclear translocation of P65. In summary, urolithin B significantly inhibits inflammation and alleviates osteoarthritis. Hence, urolithin B can be considered a potential agent suitable for the effective treatment of osteoarthritis in the future.
骨关节炎是世界范围内报道最多的退行性关节疾病。传统的治疗策略主要集中在药物治疗上，并涉及关节置换手术。这些疗法的使用受到胃肠道并发症和关节假体寿命的限制。因此，迫切需要安全有效的药物来阻止骨关节炎的进展。尿石素 B 是肠道中原花青素的代谢物，具有抗炎和抗氧化作用；然而，其在骨关节炎中的作用尚不清楚。在这项研究中，我们证明了尿石素 B 能有效地抑制炎症因子诱导的基质金属蛋白酶（MMP3 和 MMP13）的产生，并上调 II 型胶原和聚集蛋白聚糖的表达。尿石素 B 减轻了前交叉韧带横断引起的软骨侵蚀和骨赘形成。此外，尿石素 B 通过减少 Iκb-α 的磷酸化和 P65 的核易位来抑制 NF-κB 通路的激活。总之，尿石素 B 能显著抑制炎症并缓解骨关节炎。因此，尿石素 B 可以被认为是一种有潜力的适合未来有效治疗骨关节炎的药物。
