Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Biochem Pharmacol. 2024 May;223:116122. doi: 10.1016/j.bcp.2024.116122. Epub 2024 Mar 10.
Cutaneous melanoma is the deadliest form of skin cancer, and its incidence is continuing to increase worldwide in the last decades. Traditional therapies for melanoma can easily cause drug resistance, thus the treatment of melanoma remains a challenge. Various studies have focused on reversing the drug resistance. As tumors grow and progress, cancer cells face a constantly changing microenvironment made up of different nutrients, metabolites, and cell types. Multiple studies have shown that metabolic reprogramming of cancer is not static, but a highly dynamic process. There is a growing interest in exploring the relationship between melanoma andmetabolic reprogramming, one of which may belipid metabolism. This review frames the recent research progresses on lipid metabolism in melanoma.In addition, we emphasize the dynamic ability of metabolism during tumorigenesis as a target for improving response to different therapies and for overcoming drug resistance in melanoma.
皮肤黑色素瘤是皮肤癌中最致命的一种，在过去几十年中，其发病率在全球范围内持续上升。传统的黑色素瘤治疗方法很容易导致耐药性，因此黑色素瘤的治疗仍然是一个挑战。各种研究都集中在逆转耐药性上。随着肿瘤的生长和进展，癌细胞面临着由不同的营养物质、代谢物和细胞类型组成的不断变化的微环境。多项研究表明，癌细胞的代谢重编程不是静态的，而是一个高度动态的过程。人们越来越关注探索黑色素瘤与代谢重编程之间的关系，其中之一可能是脂代谢。本文综述了近年来黑色素瘤中脂代谢的研究进展。此外，我们强调了代谢在肿瘤发生过程中的动态能力，将其作为提高对不同治疗方法反应和克服黑色素瘤耐药性的靶点。
