Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Department of Dermatology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
Cancer Med. 2024 Nov;13(21):e70386. doi: 10.1002/cam4.70386.
Melanoma, a highly aggressive skin cancer, is characterized by rapid progression and a high metastatic potential, presenting significant challenges in clinical oncology. A critical aspect of melanoma biology is its metabolic reprogramming, which supports tumor growth, survival, and therapeutic resistance.
This review aims to explore the key molecular mechanisms driving metabolic alterations in melanoma and their implications for developing therapeutic strategies.
A Pubmed search was conducted to analyze literature discussing key mechanisms of the Warburg effect, mitochondrial dysfunction, enhanced lipid metabolism, epigenetic modifications, and the tumor microenvironment.
Metabolic reprogramming supports melanoma growth, proliferation, and survival. Understanding these complex metabolic dynamics provides valuable insights for developing targeted therapeutic strategies.
Potential therapeutic interventions aimed at disrupting melanoma metabolism highlight the promise of precision medicine in improving treatment outcomes in cutaneous oncology. By targeting metabolic vulnerabilities, novel treatment approaches could significantly enhance the clinical management and prognosis of melanoma.
黑色素瘤是一种侵袭性很强的皮肤癌，其特点是进展迅速、转移潜能高，给临床肿瘤学带来了重大挑战。黑色素瘤生物学的一个关键方面是其代谢重编程，这支持了肿瘤的生长、存活和治疗抵抗。
本综述旨在探讨驱动黑色素瘤代谢改变的关键分子机制及其对开发治疗策略的意义。
通过 Pubmed 搜索，分析了讨论沃伯格效应、线粒体功能障碍、增强脂质代谢、表观遗传修饰和肿瘤微环境等关键机制的文献。
代谢重编程支持黑色素瘤的生长、增殖和存活。了解这些复杂的代谢动态为开发靶向治疗策略提供了有价值的见解。
旨在破坏黑色素瘤代谢的潜在治疗干预措施强调了精准医学在改善皮肤肿瘤学治疗结果方面的前景。通过靶向代谢脆弱性，新的治疗方法可以显著提高黑色素瘤的临床管理和预后。
