Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Kafrelsheikh University, Kafr El-sheikh, Egypt.
Department of Oral Medicine, Oral Diagnosis, and Radiology, Faculty of Dentistry, Tanta University, Tanta, Egypt.
Clin Oral Investig. 2024 Mar 12;28(4):210. doi: 10.1007/s00784-024-05596-4.
The present study aimed to assess clinically and radiographically the usage of autogenous tooth bone graft (ATBG) combined with and without Simvastatin (SMV) around immediately placed dental implants in periodontally compromised sites.
Thirty-nine patients required a single extraction of periodontally compromised tooth were divided into three groups (13 patients each). Group I received immediate implant placement (IIP) without grafting. Group II received IIP with ATBG filling the gap around IIP. Group III received SMV gel mixed with ATBG around IIP. Radiographic changes were reported at the baseline, 6-, and 12-months post-surgery.
All implants achieved the success criteria with no complications. At 6- and 12-months post-surgery, group III showed a statistically lower mean ridge width loss compared to Group I and Group II (P < .001). Group II revealed less reduction in the mean alveolar ridge width compared to group I (P < .001). Group III showed a statistically significantly less MBL loss than group I and group II (P < .001). All groups showed a statistically significant increase in BD gain compared to baseline (P < .001). Group III showed statistically significant high BD compared to group II (P < .001). Group II showed statistically significantly higher mean BD gain than that of group I (P < .001).
SMV combined with ATBG boosts the hard tissue parameters around dental implants over ATBG alone. Clinical trial registration was on August 1, 2021 (NCT04992416).
ATBG with SMV in periodontally compromised sites could improve implant osseointegration and promote favorable changes in peri-implant tissues.
本研究旨在评估在牙周病损部位，应用自体牙骨移植（ATBG）联合或不联合辛伐他汀（SMV）即刻植入种植体的临床和影像学效果。
39 名患者需要拔除牙周病损的单个牙齿，将其分为三组（每组 13 名患者）。第 I 组未进行植骨即行即刻种植（IIP）；第 II 组行 IIP 并使用 ATBG 填充 IIP 周围的间隙；第 III 组在 IIP 周围使用 SMV 凝胶混合 ATBG。术后基线、6 个月和 12 个月时报告影像学变化。
所有种植体均符合成功标准，无并发症发生。术后 6 个月和 12 个月时，第 III 组的平均牙槽嵴宽度损失明显低于第 I 组和第 II 组（P<0.001）。第 II 组的平均牙槽嵴宽度减少程度明显低于第 I 组（P<0.001）。第 III 组的平均骨吸收量明显低于第 I 组和第 II 组（P<0.001）。所有组的骨结合宽度均较基线显著增加（P<0.001）。第 III 组的骨结合宽度明显高于第 II 组（P<0.001）。第 II 组的平均骨结合宽度增加明显高于第 I 组（P<0.001）。
SMV 联合 ATBG 可提高种植体周围硬组织参数，优于单独使用 ATBG。临床试验注册于 2021 年 8 月 1 日（NCT04992416）。
在牙周病损部位应用 ATBG 联合 SMV 可促进种植体骨整合，并改善种植体周围组织的变化。
