Hospital Universitari Dexeus, Barcelona, Spain.
Ginegetafe, Getafe (Madrid), España.
Gynecol Endocrinol. 2024 Mar 5;40(1):2317268. doi: 10.1080/09513590.2024.2317268. Epub 2024 Mar 12.
Vaginal dryness (VD) represents a significant concern affecting women across diverse life stages, encompassing both pre- and postmenopausal women at any age. Dyspareunia, defined by genital pain that can be experienced before, during, or after intercourse, is often associated with vaginal dryness.
This study aimed to evaluate the effectiveness and safety of a water-based vaginal lubricant with hyaluronic acid to reduce sexual discomfort associated with vaginal dryness.
A prospective, multicenter, uncontrolled clinical investigation was conducted over a three-month period in women aged 18 years or older experiencing pain or difficulty during sexual intercourse for whom the use of a vaginal lubricant was recommended.
Significant improvements were observed in the FSFI scores, indicating enhanced sexual function ( < .001). Vaginal dryness symptoms, including irritation, dryness, itching, and dyspareunia, significantly decreased after product use ( < .001).
This study contributes to the limited scientific knowledge on the application of lubricants in the context of symptoms associated with VD.
STRENGTHS & LIMITATIONS: In addition to the short study period, inherent limitations of the study design, and lack of placebo control, it is pertinent to acknowledge that some of the pros used in this study were not based on validated questionnaires. However, as far as we know, this study is the only one that analyzes well-being and sexual pleasure as results using a lubricant formulated with hyaluronic acid.
This tested vaginal lubricant with hyaluronic acid has demonstrated efficacy in improving vaginal dryness and female sexual function, particularly in reducing pain and improving lubrication during sexual intercourse, and showed a favorable safety profile, with minimal and transient adverse events.
阴道干燥（VD）是一个严重的问题，影响着不同年龄段的女性，包括任何年龄的绝经前和绝经后女性。性交时或性交前后出现的生殖器疼痛定义为性交困难，常与阴道干燥有关。
本研究旨在评估含有透明质酸的水基阴道润滑剂减少与阴道干燥相关的性不适的有效性和安全性。
在三个月的时间里，对 18 岁及以上有性交疼痛或困难且建议使用阴道润滑剂的女性进行了一项前瞻性、多中心、非对照的临床研究。
FSFI 评分显著改善，表明性功能增强（<0.001）。使用产品后，阴道干燥症状（包括刺激、干燥、瘙痒和性交困难）显著减轻（<0.001）。
本研究有助于填补关于润滑剂在与 VD 相关症状应用方面的有限科学知识。
除了研究周期短之外，研究设计的固有局限性以及缺乏安慰剂对照，值得注意的是，本研究中使用的一些指标并非基于经过验证的问卷。然而，据我们所知，这是唯一一项使用含有透明质酸的润滑剂分析作为结果的幸福感和性愉悦的研究。
该透明质酸阴道润滑剂在改善阴道干燥和女性性功能方面具有疗效，特别是在减轻疼痛和改善性交时的润滑方面，且具有良好的安全性，不良反应轻微且短暂。
