Chai Weiwen, Maskarinec Gertraud, Lim Unhee, Boushey Carol J, Wilkens Lynne R, Setiawan V Wendy, Le Marchand Loïc, Randolph Timothy W, Jenkins Isaac C, Lampe Johanna W, Hullar Meredith A J
Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE.
University of Hawai'i Cancer Center, Honolulu, HI.
Gut Microbiome (Camb). 2023;4. doi: 10.1017/gmb.2023.10. Epub 2023 Jul 13.
Consumption of probiotics and/or yogurt could be a solution for restoring the balance of the gut microbiota. This study examined associations of regular intake of probiotic supplements or yogurt with the gut microbiota among a diverse population of older adults (N=1,861; 60-72 years). Fecal microbial composition was obtained from 16S rRNA gene sequencing (V1-V3 region). General Linear Models were used to estimate the associations of probiotic supplement or yogurt intake with microbiome measures adjusting for covariates. Compared to non-yogurt consumers (N=1,023), regular yogurt consumers (≥once/week, N=818) had greater (β=0.29, =0.0003) and lower (β=-0.33, <0.0001) abundance. The directions of the above associations were consistent across the five ethnic groups but stronger among Japanese Americans ( β=0.56, =0.0009; β=-0.62, =0.0005). Regular intake of probiotic supplements (N=175) was not associated with microbial characteristics (i.e., alpha diversity and the abundance of 152 bacteria genera). is one of the predominant bacteria genera in yogurt products, which may explain the positive association between yogurt consumption and abundance. Our analyses suggest that changes in were independent of changes in abundance. Future studies may investigate whether these microbial genera and their sub-level species mediate potential pathways between yogurt consumption and health.
食用益生菌和/或酸奶可能是恢复肠道微生物群平衡的一种解决方案。本研究调查了在不同老年人群体（N = 1861；60 - 72岁）中，定期摄入益生菌补充剂或酸奶与肠道微生物群之间的关联。通过16S rRNA基因测序（V1 - V3区域）获得粪便微生物组成。使用一般线性模型来估计益生菌补充剂或酸奶摄入量与微生物组测量值之间的关联，并对协变量进行调整。与不食用酸奶的人群（N = 1023）相比，经常食用酸奶的人群（≥每周一次，N = 818）的[具体细菌名称1]丰度更高（β = 0.29，P = 0.0003），而[具体细菌名称2]丰度更低（β = -0.33，P < 0.0001）。上述关联的方向在五个种族群体中是一致的，但在日裔美国人中更强（β = 0.56，P = 0.0009；β = -0.62，P = 0.0005）。定期摄入益生菌补充剂（N = 175）与微生物特征（即α多样性和152个细菌属的丰度）无关。[具体细菌名称1]是酸奶产品中的主要细菌属之一，这可能解释了食用酸奶与[具体细菌名称1]丰度之间的正相关关系。我们的分析表明，[具体细菌名称1]的变化独立于[具体细菌名称2]丰度的变化。未来的研究可以调查这些微生物属及其亚水平物种是否介导了酸奶消费与健康之间的潜在途径。
