Joshi Ashutosh, Nigam Ayush, Narayan Mudgal Lalit, Mondal Bhaskar, Basak Trayambak
School of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Mandi, Himachal Pradesh 175075, India.
School of Chemical Sciences, Indian Institute of Technology (IIT) Mandi, Himachal Pradesh 175075, India.
Matrix Biol Plus. 2024 Feb 29;22:100144. doi: 10.1016/j.mbplus.2024.100144. eCollection 2024 Jun.
Collagen is a key component of the extracellular matrix (ECM). In the remodeling of ECM, a remarkable variation in collagen post-translational modifications (PTMs) occurs. This makes collagen a potential target for understanding extracellular matrix remodeling during pathological conditions. Over the years, scientists have gathered a huge amount of data about collagen PTM during extracellular matrix remodeling. To make such information easily accessible in a consolidated space, we have developed ColPTMScape (https://colptmscape.iitmandi.ac.in/), a dedicated knowledge base for collagen PTMs. The identified site-specific PTMs, quantitated PTM sites, and PTM maps of collagen chains are deliverables to the scientific community, especially to matrix biologists. Through this knowledge base, users can easily gain information related to the difference in the collagen PTMs across different tissues in different organisms.
胶原蛋白是细胞外基质（ECM）的关键组成部分。在细胞外基质重塑过程中，胶原蛋白的翻译后修饰（PTM）会发生显著变化。这使得胶原蛋白成为理解病理条件下细胞外基质重塑的潜在靶点。多年来，科学家们已经收集了大量关于细胞外基质重塑过程中胶原蛋白PTM的数据。为了使这些信息在一个整合的空间中易于获取，我们开发了ColPTMScape（https://colptmscape.iitmandi.ac.in/），这是一个专门用于胶原蛋白PTM的知识库。已鉴定的位点特异性PTM、定量的PTM位点以及胶原蛋白链的PTM图谱将提供给科学界，特别是基质生物学家。通过这个知识库，用户可以轻松获取与不同生物体中不同组织的胶原蛋白PTM差异相关的信息。
