从 的地上部分中分离得到的具有镇痛作用的环烯醚萜苷。
Antinociceptive iridoid glycosides from the aerial parts of .
机构信息
Department of Nuclear Medicine, General Hospital of Northern Theater Command, Shenyang 110016, China.
Department of the Food and Drug Inspection, Shenyang Joint Logistics Support Center Drug Instrument Supervision and Inspection Station, Shenyang 110026, China.
出版信息
J Asian Nat Prod Res. 2024 Jul;26(7):788-794. doi: 10.1080/10286020.2024.2326565. Epub 2024 Mar 12.
Two previously undescribed iridoid glycosides, 6'--trans-feruloyl-(4,6)-3,4-dihydro-3-ethoxypaederoside () and 6'--trans-caffeoyl-(4,6)-3,4-dihydro-2'--3-paederoside (), were isolated from the 90% EtOH extract of the air dried aerial parts of . Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (HH COSY, HMQC, and HMBC) NMR spectroscopy. The two isolated iridoid glycosides were tested for their antinociceptive properties. As a result, showed potent antinociceptive effect and its ID value (53.4 μmol/kg) was 2-fold less than those of the positive control drugs aspirin and acetaminophen.
从 的干燥地上部分的 90%乙醇提取物中分离得到两种以前未描述的裂环环烯醚萜苷：6'--反式-阿魏酰基-(4,6)-3,4-二氢-3-乙氧基滇乌头苷 () 和 6'--反式-咖啡酰基-(4,6)-3,4-二氢-2'--3-滇乌头苷 ()。通过光谱方法，如 1D 和 2D（HH COSY、HMQC 和 HMBC）NMR 光谱，对所有化合物的结构进行了阐明。测试了两种分离得到的裂环环烯醚萜苷的镇痛活性。结果表明， 具有很强的镇痛作用，其 ID 值（53.4μmol/kg）是阳性对照药物阿司匹林和对乙酰氨基酚的 2 倍。
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