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肾周脂肪组织包含一群由棕色脂肪向白色脂肪转化产生的冷诱导脂肪细胞。

Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion.

作者信息

Zhang Houyu, Li Yan, Ibáñez Carlos F, Xie Meng

机构信息

Chinese Institute for Brain Research, Zhongguancun Life Science Park, Beijing, China.

Peking University Academy for Advanced Interdisciplinary Studies, Beijing, China.

出版信息

Elife. 2024 Mar 12;13:RP93151. doi: 10.7554/eLife.93151.

DOI:10.7554/eLife.93151
PMID:38470102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10932542/
Abstract

Perirenal adipose tissue (PRAT) is a unique visceral depot that contains a mixture of brown and white adipocytes. The origin and plasticity of such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic lineage tracing to reveal the existence of a distinct subpopulation of & adipocytes that arises from brown-to-white conversion during postnatal life in the periureter region of mouse PRAT. Cold exposure restores expression and a thermogenic phenotype in this subpopulation. These cells have a transcriptome that is distinct from subcutaneous beige adipocytes and may represent a unique type of cold-recruitable adipocytes. These results pave the way for studies of PRAT physiology and mechanisms controlling the plasticity of brown/white adipocyte phenotypes.

摘要

肾周脂肪组织（PRAT）是一种独特的内脏脂肪库，其中包含棕色和白色脂肪细胞的混合物。这种细胞异质性的起源和可塑性仍然未知。在这里，我们将单核RNA测序与遗传谱系追踪相结合，以揭示在小鼠PRAT输尿管周围区域出生后生活期间从棕色向白色转化产生的一种独特的δ脂肪细胞亚群的存在。冷暴露可恢复该亚群中的表达和产热表型。这些细胞具有与皮下米色脂肪细胞不同的转录组，可能代表一种独特类型的可被寒冷招募的脂肪细胞。这些结果为PRAT生理学以及控制棕色/白色脂肪细胞表型可塑性的机制研究铺平了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/7174a56d2154/elife-93151-fig6-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/7e49609260e7/elife-93151-fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/94bb5b5e3251/elife-93151-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/276d4bfd9c6b/elife-93151-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/e54d0079e867/elife-93151-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/2a428d770309/elife-93151-fig5-figsupp1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/7174a56d2154/elife-93151-fig6-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/7e49609260e7/elife-93151-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/08c2ef8c54a6/elife-93151-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/37940c7a6848/elife-93151-fig1-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/41dd2749fc0a/elife-93151-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/a984313d932a/elife-93151-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/c9913e2da36a/elife-93151-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/94bb5b5e3251/elife-93151-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/276d4bfd9c6b/elife-93151-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/e54d0079e867/elife-93151-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/2a428d770309/elife-93151-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/0a3454061eda/elife-93151-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/478b98447595/elife-93151-fig6-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a62/10932542/7174a56d2154/elife-93151-fig6-figsupp2.jpg

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